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How to get fromDetroit to Sikestonby plane, car, train, bus, taxi, bus (Greyhound, Flixbus), or bus (Amtrak)

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There are 11 ways to get from Detroit to Sikeston by plane, car, train, bus, taxi, bus (Greyhound, Flixbus), or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barkley Regional Airport, drive

    best
    1. Fly from Detroit (DTW) to Barkley Regional Airport (PAH)plane plane DTW - PAH
    2. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    7h 2m
    $92–457

  2. Train, bus

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus bus Milwaukee
    14h 26m
    $204–424

  3. Train, drive (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain train
    3. Drive from Fulton Amtrak Station to Sikestoncar car
    15h 22m
    $234–472

  4. Drive 603.7 mi

    1. Drive from Detroit to Sikestoncar car 603.7 mi
    10h 14m
    $111–160

  5. Fly to Lambert–St. Louis International Airport, bus, taxi

    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    7h 49m
    $563–1,110

  6. Fly to Williamson County Regional Airport, bus

    1. Fly from Detroit (DTW) to Williamson County Regional Airport (MWA)plane plane DTW - MWA
    2. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    9h 6m
    $160–633

  7. Fly to Nashville, bus, drive

    1. Fly from Detroit (DTW) to Nashville (BNA)plane plane DTW - BNA
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Drive from Paducah Bus Station to Sikestoncar car
    8h 52m
    $486–1,156

  8. Fly to Memphis, bus

    1. Fly from Detroit (DTW) to Memphis (MEM)plane plane DTW - MEM
    2. Take the bus from Tornado Bus Co - West Memphis to Flying J - Matthewsbus bus
    9h 5m
    $237–1,008

  9. Fly to Cape Girardeau Municipal Airport, taxi

    1. Fly from Detroit (DTW) to Cape Girardeau Municipal Airport (CGI)plane plane DTW - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    7h 8m
    $242–802

  10. Bus

    1. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus Greyhound US0160
    2. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus bus Milwaukee
    16h 10m
    $153–320

  11. Bus via Woodward & Baltimore

    1. Take the bus from Detroit to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus bus Milwaukee
    16h 51m
    $204–374

Detroit (DTW) to Barkley Regional Airport (PAH) flights

Calendar21Weekly Planes
Duration5h 33mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Detroit to Sikeston.ExpandLaunch map view
  • Distance: 534.1 mi
  • Duration: 7h 2m

What companies run services between Detroit, MI, USA and Sikeston, MO, USA?

You can take a bus from Detroit Bus Station to Sikeston via Chicago Bus Station, Harrison & Jefferson, Cicero & 24th Place Terminal, Tornado Bus Co - Chicago, and Flying J - Matthews in around 16h 10m.

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