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How to get fromDetroit to South Carolinaby plane, bus (Greyhound), bus, train, car, or taxi

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There are 7 ways to get from Detroit to South Carolina by plane, bus (Greyhound), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Detroit to Greenville–Spartanburg International Airport

    best
    1. Fly from Detroit (DTW) to Greenville–Spartanburg International Airport (GSP)plane plane DTW - GSP
    3h 55m
    $147–697

  2. Bus (Greyhound)

    1. Take the bus from Detroit Bus Station to Charlotte Bus Stationbus bus Greyhound US0140
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus Greyhound US0643S
    24h 54m
    $148–285

  3. Bus, train

    1. Take the bus from Detroit Bus Station to Toledo Bus Stopbus bus
    2. Take the train from Toledo to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    26h 35m
    $356–767

  4. Drive 813.3 mi

    1. Drive from Detroit to Charlestoncar car 813.3 mi
    14h 28m
    $149–215

  5. Fly Detroit to Charlotte Douglas International Airport, taxi

    1. Fly from Detroit (DTW) to Charlotte Douglas International Airport (CLT)plane plane DTW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 17m
    $192–752

  6. Fly Detroit to Charleston International Airport

    1. Fly from Detroit (DTW) to Charleston International Airport (CHS)plane plane DTW - CHS
    5h 7m
    $504–1,204

  7. Bus to Cleveland-Hopkins International Airport, fly to Charlotte Douglas International Airport, taxi

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Charlotte Douglas International Airport (CLT)plane plane CLE - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    6h 46m
    $207–798

Detroit to South Carolina by bus (Greyhound)

Calendar7Weekly Buses
Duration24h 54mAverage Duration
Ticket$148Cheapest Price
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Questions & Answers

Map of how to get from Detroit to South Carolina.ExpandLaunch map view
  • Distance: 543.2 mi
  • Duration: 3h 55m

What companies run services between Detroit, MI, USA and South Carolina, USA?

Delta, American Airlines, and Southwest Airlines fly from Detroit (DTW) to Greenville–Spartanburg International Airport (GSP) every 3 hours. Alternatively, you can take a bus from Detroit Bus Station to Transit Mall via Charlotte Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 24h 54m.

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Need to know: Greyhound

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