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How to get fromDomodossola to Sienaby train (Trenitalia), bus, car, plane, or train

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There are 6 ways to get from Domodossola to Siena by train (Trenitalia), bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Domodossola to Milano Centraletrain train Ec
    2. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    3. Take the train from Firenze S.M.N. to Sienatrain train Re
    5h 43m
    €74–184

  2. Bus

    cheapest
    1. Take the bus from Domodossola - Stazione Ferroviaria to Aeroporto Malpensa - Terminal 1bus bus 3
    2. Take the bus from Milan Malpensa Airport 1 P13 to Siena Central Train Stationbus bus Itabus
    9h 10m
    €36–69

  3. Bus via Florence

    1. Take the bus from Domodossola to Milano Centralebus bus Re4
    2. Take the bus from Milano - Famagosta to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    8h 44m

  4. Drive  489.6 km

    1. Drive from Domodossola to Sienacar car 489.6 km
    4h 57m
    €78–112

  5. Bus, fly, train

    1. Take the bus from Domodossola - Stazione Ferroviaria to Aeroporto Malpensa - Terminal 1bus bus
    2. Fly from Milano Malpensa Airport (MXP) to Florence Peretola Airport (FLR)plane plane MXP - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 48m
    €112–250

  6. Train via Rho (Trenitalia)

    1. Take the train from Domodossola to Rho-Fiera Milanotrain train Re
    2. Take the train from Rho-Fiera Milano to Firenze S.M.N.train train Fr
    3. Take the train from Firenze S.M.N. to Sienatrain train Re
    7h 21m
    €70–136

Domodossola to Siena by train

Calendar4Weekly Trains
Duration5h 43mAverage Duration
Ticket€74Cheapest Price
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Questions & Answers

Map of how to get from Domodossola to Siena.ExpandLaunch map view
  • Distance: 518.5 km
  • Duration: 5h 43m

What companies run services between Domodossola, Italy and Siena, Italy?

You can take a train from Domodossola to Siena via Milano Centrale and Firenze S.M.N. in around 5h 43m. Alternatively, you can take a bus from Domodossola to Siena via Milano Centrale, Milano, Stazione Centrale, famagosta m2, Milano - Famagosta, and Florence Villa Constanza Bus Station in around 8h 44m.

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