Rome2Rio

How to get fromDomodossola to Sienaby bus, train, car, or train (Trenitalia)

Find Transport to Siena

See all options

There are 6 ways to get from Domodossola to Siena by bus, train, car, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Domodossola to Milano Centralebus bus Re4
    2. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    3. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    5h 54m

  2. Train

    cheapest
    1. Take the train from Domodossola to Rho-Fiera Milanotrain train Re
    2. Take the train from Milano Rogoredo to Bologna centraletrain train
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    7h 1m
    €60–111

  3. Bus, train via Bologna

    1. Take the bus from Domodossola to Rho Fiera Milanobus bus Re4
    2. Take the train from Milano Rogoredo to Bologna centraletrain train
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    6h 22m

  4. Drive  489.6 km

    1. Drive from Domodossola to Sienacar car 489.6 km
    4h 57m
    €88–127

  5. Bus

    1. Take the bus from Domodossola to Rho Fiera Milanobus bus Re4
    2. Take the bus from Milano, Autostazione Lampugnano to Sienabus bus N528 / ...
    7h 32m

  6. Bus via Florence

    1. Take the bus from Domodossola to Milano Centralebus bus Re4
    2. Take the bus from Milano - Famagosta to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    8h 53m

Comparing Your Travel Options

Map of how to get from Domodossola to Siena.ExpandLaunch map view
  • Distance: 514.3 km
  • Duration: 5h 54m

What companies run services between Domodossola, Italy and Siena, Italy?

You can take a train from Domodossola to Siena via Milano Rogoredo, Bologna Centrale, and Firenze S.M.N. in around 7h 1m. Alternatively, you can take a bus from Domodossola to Siena via Rho Fiera Milano, Rho Fieramilano, Lampugnano, and Milano, Autostazione Lampugnano in around 7h 32m.

Train operators
Bus operators

Want to know more about travelling around Italy

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Italy Travel Guides

Read the travel guideItaly Travel Guides

Booking & Getting There