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How to get fromDowningtown to Knoxvilleby train, plane, bus, car, or subway

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There are 10 ways to get from Downingtown to Knoxville by train, plane, bus, car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    4h 35m
    $238–1,044

  2. Drive 588.9 mi

    cheapest
    1. Drive from Downingtown to Knoxvillecar car 588.9 mi
    10h 32m
    $108–156

  3. Train, bus

    1. Take the train from Downingtown Amtrak to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    16h 1m
    $178–243

  4. Train, train to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane plane BWI - TYS
    5h 35m
    $209–1,491

  5. Train to Laguardia Airport, fly to Mcghee Tyson Airport

    1. Take the train from Downingtown Amtrak to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Mcghee Tyson Airport (TYS)plane plane LGA - TYS
    6h 43m
    $258–1,003

  6. Train, train to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane plane DCA - TYS
    6h 25m
    $279–1,848

  7. Train to Philadelphia International Airport, fly to Asheville Regional Airport, drive

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Asheville Regional Airport (AVL)plane plane PHL - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 34m
    $125–549

  8. Train, subway to Washington Dulles International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the subway from Farragut West, Blue/Orange/Silver Line Track 2 Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    4. Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane plane IAD - TYS
    6h 50m
    $199–1,347

  9. Bus

    1. Take the bus from Philadelphia to New Yorkbus bus Ppb 8541 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    18h 51m
    $222–342

  10. Train, bus via Philadelphia

    1. Take the train from Downingtown to Jefferson Stationtrain train Pao
    2. Take the bus from Philadelphia Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 48m
    $125–158

Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS) flights

Calendar71Weekly Planes
Duration3h 33mAverage Duration
Ticket$173Cheapest Price
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Questions & Answers

Map of how to get from Downingtown to Knoxville.ExpandLaunch map view
  • Distance: 605.6 mi
  • Duration: 4h 35m

What companies run services between Downingtown, PA, USA and Knoxville, TN, USA?

You can take a bus from Lancaster Av & Green St - MBNS to Knoxville via West Chester Transit Center, 69th St Transit Center, 69th St Transit Center South Terminal, Chestnut St & 30th St, Philadelphia, New York, 42 St-Times Square, Canal St, New York, and Knoxville in around 18h 51m.

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