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How to get fromDowningtown to Louisvilleby train, plane, car, bus (Greyhound, Amtrak), or bus

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There are 9 ways to get from Downingtown to Louisville by train, plane, car, bus (Greyhound, Amtrak), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Blue Grass Airport, drive

    best
    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Blue Grass Airport (LEX)plane plane PHL - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 34m
    $130–699

  2. Drive  634.4 mi

    cheapest
    1. Drive from Downingtown to Louisvillecar car 634.4 mi
    11h 7m
    $105–152

  3. Bus

    1. Take the bus from King of Prussia Park & Ride to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    22h 10m
    $140–238

  4. Train, bus (Amtrak)

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    26h 14m
    $499–822

  5. Train to Philadelphia International Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF)plane plane PHL - SDF
    5h 53m
    $210–1,134

  6. Train, train to Baltimore-Washington International Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Louisville International Airport (SDF)plane plane BWI - SDF
    6h 39m
    $172–1,480

  7. Train, train to Ronald Reagan Washington National Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Louisville International Airport (SDF)plane plane DCA - SDF
    7h 33m
    $202–1,637

  8. Train, train to Newark Liberty International Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    3. Fly from Newark Liberty International Airport (EWR) to Louisville International Airport (SDF)plane plane EWR - SDF
    7h 23m
    $178–800

  9. Train, bus via Lafayette

    1. Take the train from Downingtown to Jefferson Stationtrain train Pao
    2. Take the bus from Philadelphia Bus Station to Lafayette Bus Stopbus bus
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    24h 52m
    $153–245

Downingtown to Louisville by bus

Calendar7Weekly Buses
Duration22h 10mAverage Duration
Ticket$140Cheapest Price
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Comparing Your Travel Options

Map of how to get from Downingtown to Louisville.ExpandLaunch map view
  • Distance: 628.9 mi
  • Duration: 5h 34m

What companies run services between Downingtown, PA, USA and Louisville, KY, USA?

You can take a bus from Lancaster Av & Green St - MBNS to Louisville, KY via West Chester Transit Center, Plaza at King of Prussia, South Gulph Rd & Bill Smith Blvd - FS, King of Prussia Park & Ride, and Indianapolis Union Station in around 22h 10m.

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