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How to get fromDowningtown to Louisvilleby train, plane, bus, car, subway, or bus (Greyhound, Amtrak)

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There are 10 ways to get from Downingtown to Louisville by train, plane, bus, car, subway, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Louisville International Airport

    best
    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF)plane plane PHL - SDF
    5h 46m
    $151–825

  2. Train to Philadelphia International Airport, fly to Blue Grass Airport, drive

    cheapest
    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Blue Grass Airport (LEX)plane plane PHL - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 33m
    $98–501

  3. Train, bus

    1. Take the train from Downingtown Amtrak to Harrisburgtrain train
    2. Take the bus from Harrisburg Bus Station to Cincinnatibus bus
    3. Take the bus from Cincinnati to Louisvillebus bus
    16h 22m
    $102–209

  4. Train, bus via Indianapolis

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    26h 9m
    $240–563

  5. Drive  634.4 mi

    1. Drive from Downingtown to Louisvillecar car 634.4 mi
    11h 7m
    $116–168

  6. Train, train to Baltimore-Washington International Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Louisville International Airport (SDF)plane plane BWI - SDF
    6h 34m
    $143–1,371

  7. Train, train to Ronald Reagan Washington National Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Louisville International Airport (SDF)plane plane DCA - SDF
    7h 26m
    $193–1,628

  8. Train, subway to Washington Dulles International Airport, fly to Louisville International Airport

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    4. Fly from Washington Dulles International Airport (IAD) to Louisville International Airport (SDF)plane plane IAD - SDF
    7h 56m
    $138–1,277

  9. Train to Philadelphia International Airport, fly to Covington, bus

    1. Take the train from Downingtown Amtrak to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Covington (CVG)plane plane PHL - CVG
    3. Take the bus from Cincinnati to Louisvillebus bus
    8h 5m
    $181–969

  10. Bus

    1. Take the bus from King of Prussia Park & Ride to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus Greyhound US0100 / ...
    22h
    $130–218

Downingtown to Louisville by train, bus, and foot

Calendar5Weekly Services
Duration16h 22mAverage Duration
Ticket$102Cheapest Price
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Comparing Your Travel Options

Map of how to get from Downingtown to Louisville.ExpandLaunch map view
  • Distance: 620.4 mi
  • Duration: 5h 46m

What companies run services between Downingtown, PA, USA and Louisville, KY, USA?

You can take a bus from Lancaster Av & Green St - MBNS to Louisville Bus Station via West Chester Transit Center, Plaza at King of Prussia, South Gulph Rd & Bill Smith Blvd - FS, King of Prussia Park & Ride, and Indianapolis Union Station in around 22h.

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