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How to get fromDubuque to St. Louisby car, plane, bus, or train

Find Transport to St. Louis

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There are 6 ways to get from Dubuque to St. Louis by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Quad City International Airport, fly

    best
    1. Drive from Dubuque to Moline-Airport-MLIcar car
    2. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    5h 40m
    $87–474

  2. Drive  297.3 mi

    cheapest
    1. Drive from Dubuque to St. Louiscar car 297.3 mi
    6h 38m
    $55–79

  3. Drive, bus, train

    1. Drive from Dubuque to Twixt Town Rd Transfercar car
    2. Take the bus from GTC Bay 9 to Court St Transportation Centerbus bus
    3. Take the bus from Iowa City to Chicago Bus Stationbus bus
    4. Take the train from Chicago Union Station to St. Louistrain train
    15h 4m

  4. Drive to The Eastern Iowa Airport, fly

    1. Drive from Dubuque to Cedar-Rapids-Airport-CIDcar car
    2. Fly from The Eastern Iowa Airport (CID) to Lambert–St. Louis International Airport (STL)plane plane CID - STL
    6h 3m
    $93–494

  5. Drive to General Mitchell International Airport, fly

    1. Drive from Dubuque to Milwaukee-Airport-MKEcar car
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 16m
    $513–896

  6. Drive, bus

    1. Drive from Dubuque to Twixt Town Rd Transfercar car
    2. Take the bus from GTC Bay 9 to Court St Transportation Centerbus bus
    3. Take the bus from Iowa City to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    16h 3m

Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL) flights

Calendar90Weekly Planes
Duration5h 10mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Dubuque to St. Louis.ExpandLaunch map view
  • Distance: 280.1 mi
  • Duration: 5h 40m

What companies run services between Dubuque, IA, USA and St. Louis, MO, USA?

There is no direct connection from Dubuque to St. Louis. However, you can drive to Moline-Airport-MLI airport, fly to Lambert–St. Louis International Airport (STL), walk to LAMBERT AIRPORT TERMINAL #1 station, then take the train to CIVIC CENTER station. Alternatively, you can take a vehicle from Dubuque to St. Louis via Twixt Town Rd Transfer, GTC Bay 5, GTC Bay 9, Iowa City, Chicago Bus Station, and Chicago Union Station in around 15h 4m.

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