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How to get fromDuke University to Knoxvilleby plane, bus, shuttle, car, train, or taxi

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There are 7 ways to get from Duke University to Knoxville by plane, bus, shuttle, car, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Mcghee Tyson Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS)plane plane RDU - TYS
    6h 21m
    $155–727

  2. Drive 316.2 mi

    cheapest
    1. Drive from Duke University to Knoxvillecar car 316.2 mi
    6h 16m
    $58–84

  3. Bus, shuttle, drive

    1. Take the bus from Durham to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    12h 54m
    $379–438

  4. Train to Piedmont Triad International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS)plane plane GSO - TYS
    7h 15m
    $213–901

  5. Fly Raleigh-Durham International Airport to Nashville, drive

    1. Fly from Raleigh-Durham International Airport (RDU) to Nashville (BNA)plane plane RDU - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 6m
    $425–1,157

  6. Train to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    7h 41m
    $197–827

  7. Train, bus, taxi, shuttle, drive

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Wythevillebus bus
    4. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    5. Take the taxi from Bristol Exit 5 Park & Ride Lot to Black Bear Resorttaxi taxi
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Knoxvillecar car
    13h 1m
    $320–416

Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) flights

Calendar128Weekly Planes
Duration3h 55mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Duke University to Knoxville.ExpandLaunch map view
  • Distance: 323.3 mi
  • Duration: 6h 21m

What companies run services between Duke University, NC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) hourly.

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