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How to get fromDuke University to Knoxvilleby plane, train, bus, taxi, shuttle, or car

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There are 7 ways to get from Duke University to Knoxville by plane, train, bus, taxi, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Mcghee Tyson Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS)plane plane RDU - TYS
    6h 22m
    $190–977

  2. Drive  316.2 mi

    cheapest
    1. Drive from Duke University to Knoxvillecar car 316.2 mi
    6h 17m
    $54–79

  3. Train, bus, taxi, shuttle, drive

    1. Take the train from Durham Amtrak Station to High Pointtrain train
    2. Take the bus from Forsyth Hospital to Boonebus bus
    3. Take the taxi from Boone to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    12h 14m
    $322–390

  4. Bus to Piedmont Triad International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS)plane plane GSO - TYS
    6h 58m
    $214–976

  5. Fly Raleigh-Durham International Airport to Nashville, drive

    1. Fly from Raleigh-Durham International Airport (RDU) to Nashville (BNA)plane plane RDU - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 16m
    $104–472

  6. Train to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    7h 31m
    $252–1,007

  7. Train, bus, shuttle, drive

    1. Take the train from Durham Amtrak Station to High Pointtrain train
    2. Take the bus from Forsyth Hospital to Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    12h 36m
    $286–324

Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) flights

Calendar116Weekly Planes
Duration4h 8mAverage Duration
Ticket$137Cheapest Price
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Comparing Your Travel Options

Map of how to get from Duke University to Knoxville.ExpandLaunch map view
  • Distance: 323.3 mi
  • Duration: 6h 22m

What companies run services between Duke University, NC, USA and Knoxville, TN, USA?

American Airlines, Delta, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) hourly.

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