Rome2Rio

How to get fromDuke University to Knoxvilleby plane, train, bus, taxi, shuttle, or car

Find Transport to Knoxville

See all options

There are 7 ways to get from Duke University to Knoxville by plane, train, bus, taxi, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Mcghee Tyson Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS)plane plane RDU - TYS
    6h 19m
    $160–777

  2. Drive  316.2 mi

    cheapest
    1. Drive from Duke University to Knoxvillecar car 316.2 mi
    6h 17m
    $58–84

  3. Train, bus, taxi, shuttle, drive

    1. Take the train from Durham Amtrak Station to High Pointtrain train
    2. Take the bus from Forsyth Hospital to Boonebus bus
    3. Take the taxi from Boone to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    12h 14m
    $306–376

  4. Train to Piedmont Triad International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS)plane plane GSO - TYS
    7h 15m
    $220–996

  5. Fly Raleigh-Durham International Airport to Nashville, drive

    1. Fly from Raleigh-Durham International Airport (RDU) to Nashville (BNA)plane plane RDU - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 6m
    $425–1,157

  6. Train to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    7h 37m
    $187–867

  7. Train, bus, shuttle, drive

    1. Take the train from Durham Amtrak Station to High Pointtrain train
    2. Take the bus from Forsyth Hospital to Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    12h 36m
    $270–310

Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) flights

Calendar131Weekly Planes
Duration3h 50mAverage Duration
Ticket$105Cheapest Price
See schedules

Questions & Answers

Map of how to get from Duke University to Knoxville.ExpandLaunch map view
  • Distance: 323.3 mi
  • Duration: 6h 19m

What companies run services between Duke University, NC, USA and Knoxville, TN, USA?

American Airlines, Delta, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) hourly.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides