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How to get fromDuluth to Mayo Clinicby bus, car, or plane

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There are 6 ways to get from Duluth to Mayo Clinic by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Duluth to St. Paulbus bus Jefferson 912 / ...
    2. Take the bus from St. Paul to Rochester, MNbus bus Minneapolis / ...
    4h 53m
    $72–100

  2. Fly to Rochester

    cheapest
    1. Fly from Duluth International Airport (DLH) to Rochester (RST)plane plane DLH - RST
    7h 20m
    $41–282

  3. Drive 226.2 mi

    1. Drive from Duluth to Mayo Cliniccar car 226.2 mi
    3h 50m
    $42–60

  4. Bus via Minneapolis Airport (MSP)

    1. Take the bus from Duluth, MN to Minneapolis-St. Paul International Airportbus bus Duluth
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    6h 25m
    $98–116

  5. Bus via Bloomington

    1. Take the bus from Landline - Duluth Int'l Airport to Landline - MSP Terminal-1 Lindberghbus bus Landline to MSP
    2. Take the bus from Bloomington East 82nd St. & 28th Ave. to 3rd Ave. SW & 2nd St. SWbus bus Twin Cities
    7h 45m
    $64–90

  6. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Duluth International Airport (DLH) to Minneapolis–Saint Paul International Airport (MSP)plane plane DLH - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 30m
    $98–384

Duluth International Airport (DLH) to Rochester (RST) flights

Calendar35Weekly Planes
Duration5h 55mAverage Duration
Ticket$42Cheapest Price
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Questions & Answers

Map of how to get from Duluth to Mayo Clinic.ExpandLaunch map view
  • Distance: 228 mi
  • Duration: 4h 53m

What companies run services between Duluth, MN, USA and Mayo Clinic, MN, USA?

You can take a bus from Duluth to Mayo Clinic via St. Paul and Rochester in around 4h 53m. Alternatively, Delta, United Airlines, and American Airlines fly from Duluth International Airport (DLH) to Rochester (RST) 5 times a day.

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