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How to get fromDurham to Chicagoby train, plane, train (Amtrak), bus (Flixbus), car, or bus

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There are 10 ways to get from Durham to Chicago by train, plane, train (Amtrak), bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Boston Logan Airport, fly to Chicago Midway International Airport

    best
    1. Take the train from Durham Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Chicago Midway International Airport (MDW)plane plane BOS - MDW
    6h 16m
    $128–526

  2. Train, bus to Manchester Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the train from Durham Station to Bostontrain train
    2. Take the bus from Boston to Boston Manchester Airportbus bus
    3. Fly from Manchester Airport (MHT) to Chicago O'Hare International Airport (ORD)plane plane MHT - ORD
    8h 30m
    $108–405

  3. Train (Amtrak)

    1. Take the train from Durham Station to Bostontrain train Downeaster
    2. Take the train from Boston to Chicago Union Stationtrain train Lake Shore Limited
    24h 52m
    $587–956

  4. Bus (Flixbus)

    1. Take the bus from Portsmouth Bus Stop to New York Midtownbus bus FlixBus N2615
    2. Take the bus from New York Midtown to Chicago Bus Stationbus bus FlixBus N2640 / ...
    30h 18m
    $200–306

  5. Drive  986.3 mi

    1. Drive from Durham to Chicagocar car 986.3 mi
    18h 6m
    $180–260

  6. Train to Boston Logan Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Durham Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Chicago O'Hare International Airport (ORD)plane plane BOS - ORD
    6h 38m
    $638–1,056

  7. Train to Portland, fly to Chicago O'Hare International Airport

    1. Take the train from Durham Station to Portlandtrain train
    2. Fly from Portland (PWM) to Chicago O'Hare International Airport (ORD)plane plane PWM - ORD
    7h 10m
    $115–468

  8. Train to Portland, fly to Chicago Midway International Airport

    1. Take the train from Durham Station to Portlandtrain train
    2. Fly from Portland (PWM) to Chicago Midway International Airport (MDW)plane plane PWM - MDW
    9h 2m
    $135–608

  9. Train, bus to Manchester Airport, fly to Chicago Midway International Airport

    1. Take the train from Durham Station to Bostontrain train
    2. Take the bus from Boston to Boston Manchester Airportbus bus
    3. Fly from Manchester Airport (MHT) to Chicago Midway International Airport (MDW)plane plane MHT - MDW
    7h 55m
    $128–495

  10. Train to Boston Logan Airport, fly to General Mitchell International Airport, train

    1. Take the train from Durham Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to General Mitchell International Airport (MKE)plane plane BOS - MKE
    3. Take the train from Milwaukee to Chicago Union Stationtrain train
    8h 37m
    $733–2,040

Durham to Chicago by train and subway (Amtrak)

Calendar7Weekly Services
Duration24h 52mAverage Duration
Ticket$587Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Chicago.ExpandLaunch map view
  • Distance: 932.9 mi
  • Duration: 6h 16m

What companies run services between Durham, NH, USA and Chicago, IL, USA?

You can take a train from Durham Station to Chicago Union Station via Boston, North Station, Back Bay, and Boston in around 24h 52m. Alternatively, you can take a train from Durham Station to Chicago Bus Station via Dover, Dover Transportation Center, Hanover Station, Portsmouth Bus Stop, and New York Midtown in around 30h 18m.

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