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How to get fromDurham (Station) to Chicagoby bus, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

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There are 6 ways to get from Durham (Station) to Chicago by bus, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Chicago Midway International Airport (MDW)plane plane RDU - MDW
    4h 48m
    $156–310

  2. Bus to Piedmont Triad International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Chicago O'Hare International Airport (ORD)plane plane GSO - ORD
    5h 10m
    $115–460

  3. Bus

    1. Take the bus from Durham to Washington Union Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Washington Union Station to Chicago Bus Stationbus bus Greyhound US0164
    23h 20m
    $140–284

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train Piedmont / ...
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train Floridian
    26h 7m
    $348–767

  5. Drive 764.3 mi

    1. Drive from Durham (Station) to Chicagocar car 764.3 mi
    13h 29m
    $140–202

  6. Bus to Raleigh-Durham International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Chicago O'Hare International Airport (ORD)plane plane RDU - ORD
    5h 26m
    $176–760

Durham (Station) to Chicago by bus

Calendar28Weekly Buses
Duration23h 20mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Durham (Station) to Chicago.ExpandLaunch map view
  • Distance: 658.8 mi
  • Duration: 4h 48m

What companies run services between Durham (Station), NC, USA and Chicago, IL, USA?

You can take a bus from Durham to Chicago Bus Station via Washington Union Station in around 23h 20m. Alternatively, you can take a train from Durham Amtrak Station to Chicago Union Station via Raleigh Union Station in around 26h 7m.

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