Rome2Rio

How to get fromDurham (Station) to St. Louisby bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Find Transport to St. Louis

See all options

There are 7 ways to get from Durham (Station) to St. Louis by bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    4h 59m
    $557–1,008

  2. Bus via Columbus

    cheapest
    1. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to St Louis Bus Stationbus bus
    22h
    $107–233

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    20h 15m
    $144–280

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 53m
    $433–957

  5. Drive 755.6 mi

    1. Drive from Durham (Station) to St. Louiscar car 755.6 mi
    13h 42m
    $138–200

  6. Bus to Piedmont Triad International Airport, fly

    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    6h 50m
    $171–808

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    7h 28m
    $166–755

Durham (Station) to St. Louis by bus

Calendar24Weekly Buses
Duration20h 15mAverage Duration
Ticket$144Cheapest Price
See schedules

Questions & Answers

Map of how to get from Durham (Station) to St. Louis.ExpandLaunch map view
  • Distance: 696.4 mi
  • Duration: 4h 59m

What companies run services between Durham (Station), NC, USA and St. Louis, MO, USA?

You can take a bus from Durham to St Louis Bus Station via Atlanta Bus Station in around 20h 15m. Alternatively, you can take a train from Durham Amtrak Station to St. Louis via Raleigh Union Station and Chicago Union Station in around 31h 53m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers