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How to get fromDurham to Charlestonby train (Amtrak), bus (Greyhound), car, plane, or train

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There are 7 ways to get from Durham to Charleston by train (Amtrak), bus (Greyhound), car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Durham Amtrak Station to Selma Stationtrain train Carolinian
    2. Take the train from Selma Station to Charleston Amtrak Stationtrain train Palmetto
    6h 50m
    $180–286

  2. Drive  259.2 mi

    cheapest
    1. Drive from Durham to Charlestoncar car 259.2 mi
    5h 41m
    $48–69

  3. Bus (Greyhound)

    1. Take the bus from Raleigh Bus Station to Charleston Bus Stationbus bus Greyhound US0645S
    10h 2m
    $58–90

  4. Fly Raleigh-Durham International Airport to Charleston International Airport

    1. Fly from Raleigh-Durham International Airport (RDU) to Charleston International Airport (CHS)plane plane RDU - CHS
    7h 4m
    $276–558

  5. Train to Piedmont Triad International Airport, fly to Charleston International Airport

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Charleston International Airport (CHS)plane plane GSO - CHS
    7h 18m
    $132–558

  6. Train to Charlotte Douglas International Airport, fly to Charleston International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Charleston International Airport (CHS)plane plane CLT - CHS
    7h 22m
    $139–512

  7. Train to Charlotte Douglas International Airport, fly to Columbia, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Columbia (CAE)plane plane CLT - CAE
    3. Drive from Columbia-Airport-CAE to Charlestoncar car
    7h 34m
    $142–460

Durham to Charleston by bus (Greyhound)

Calendar7Weekly Buses
Duration10h 2mAverage Duration
Ticket$58Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Charleston.ExpandLaunch map view
  • Distance: 288.9 mi
  • Duration: 6h 50m

What companies run services between Durham, NC, USA and Charleston, SC, USA?

You can take a train from Durham Amtrak Station to Charleston via Selma Station and Charleston Amtrak Station in around 6h 50m. Alternatively, Greyhound USA operates a bus from Raleigh Bus Station to Charleston Bus Station once daily. Tickets cost $50–80 and the journey takes 6h 40m.

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