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How to get fromDurham to Hartsvilleby bus (Flixbus), train (Amtrak), car, plane, taxi, or bus

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There are 5 ways to get from Durham to Hartsville by bus (Flixbus), train (Amtrak), car, plane, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Raleigh Bus Station to Florencebus bus FlixBus N2472
    4h 48m
    $88–122

  2. Drive 145.8 mi

    cheapest
    1. Drive from Durham to Hartsvillecar car 145.8 mi
    3h 8m
    $27–39

  3. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Selma Stationtrain train Carolinian
    2. Take the train from Selma Station to Florence Stationtrain train Palmetto
    5h 34m
    $133–216

  4. Fly, taxi

    1. Fly from Raleigh-Durham International Airport (RDU) to Florence Regional Airport (FLO)plane plane RDU - FLO
    2. Take the taxi from Florence Regional Airport (FLO) to Hartsvilletaxi taxi
    6h 28m
    $129–426

  5. Bus, line 100 bus, taxi

    1. Take the bus from Pettigrew St at Mangum St to Regional Transit Centerbus bus 705 / ...
    2. Take the bus from Regional Transit Center to Blount St at GoRaleigh Stationbus bus 100
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    4. Take the taxi from Florence to Hartsvilletaxi taxi
    6h 10m
    $105–148

Raleigh-Durham International Airport (RDU) to Florence Regional Airport (FLO) flights

Calendar27Weekly Planes
Duration5h 18mAverage Duration
Ticket$48Cheapest Price
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Questions & Answers

Map of how to get from Durham to Hartsville.ExpandLaunch map view
  • Distance: 191.9 mi
  • Duration: 4h 48m

What companies run services between Durham, NC, USA and Hartsville, SC, USA?

Jefferson Lines operates a bus from Raleigh Bus Station to Florence once daily. Tickets cost $40–60 and the journey takes 2h 45m. Flixbus USA also services this route 5 times a week. Alternatively, you can take a train from Durham Amtrak Station to Hartsville via Selma Station and Florence Station in around 5h 34m.

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