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How to get fromDurham to Knoxvilleby plane, train, bus, taxi, shuttle, or car

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There are 6 ways to get from Durham to Knoxville by plane, train, bus, taxi, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Mcghee Tyson Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS)plane plane RDU - TYS
    5h 50m
    $154–726

  2. Drive 317.8 mi

    cheapest
    1. Drive from Durham to Knoxvillecar car 317.8 mi
    6h 16m
    $58–84

  3. Train, bus, taxi, shuttle, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte Airport to Hickory Airportbus bus
    3. Take the bus from Hickory Airport to Blowing Rock - Tanger Outletsbus bus
    4. Take the taxi from Blowing Rock - Tanger Outlets to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    12h 21m
    $418–533

  4. Train to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    6h 21m
    $199–822

  5. Fly Raleigh-Durham International Airport to Nashville, drive

    1. Fly from Raleigh-Durham International Airport (RDU) to Nashville (BNA)plane plane RDU - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 36m
    $424–1,156

  6. Train, bus, shuttle, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    12h 26m
    $379–454

Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) flights

Calendar128Weekly Planes
Duration3h 55mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Durham to Knoxville.ExpandLaunch map view
  • Distance: 320.9 mi
  • Duration: 5h 50m

What companies run services between Durham, NC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) hourly.

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