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How to get fromDurham to Knoxvilleby plane, train, bus, taxi, shuttle, or car

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There are 6 ways to get from Durham to Knoxville by plane, train, bus, taxi, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Mcghee Tyson Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS)plane plane RDU - TYS
    5h 57m
    $169–876

  2. Drive  317.8 mi

    cheapest
    1. Drive from Durham to Knoxvillecar car 317.8 mi
    6h 18m
    $58–84

  3. Train, bus, taxi, shuttle, drive

    1. Take the train from Durham Amtrak Station to High Pointtrain train
    2. Take the bus from Forsyth Hospital to Boonebus bus
    3. Take the taxi from Boone to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    10h 46m
    $302–368

  4. Train to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    6h 4m
    $192–860

  5. Fly Raleigh-Durham International Airport to Nashville, drive

    1. Fly from Raleigh-Durham International Airport (RDU) to Nashville (BNA)plane plane RDU - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 36m
    $834–1,156

  6. Train, bus, shuttle, drive

    1. Take the train from Durham Amtrak Station to High Pointtrain train
    2. Take the bus from Forsyth Hospital to Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    11h 16m
    $268–304

Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) flights

Calendar159Weekly Planes
Duration4h 23mAverage Duration
Ticket$115Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Knoxville.ExpandLaunch map view
  • Distance: 320.9 mi
  • Duration: 5h 57m

What companies run services between Durham, NC, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) hourly.

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