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How to get fromDurham to Lancasterby bus (Flixbus, Greyhound), train (Amtrak), car, bus, plane, or train

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There are 6 ways to get from Durham to Lancaster by bus (Flixbus, Greyhound), train (Amtrak), car, bus, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Durham to Washington Union Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus Greyhound US0430
    11h 51m
    $71–120

  2. Drive  360.2 mi

    cheapest
    1. Drive from Durham to Lancastercar car 360.2 mi
    6h 50m
    $62–89

  3. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to 30th Street Stationtrain train Carolinian
    2. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train Keystone Service / ...
    13h 59m
    $301–468

  4. Bus to Raleigh-Durham International Airport, fly to Harrisburg International Airport, line 18 bus

    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Harrisburg International Airport (MDT)plane plane RDU - MDT
    3. Take the bus from AMTRAK ETown to W. Chestnut & Water St.bus bus
    9h 39m

  5. Bus to Raleigh-Durham International Airport, fly to Philadelphia International Airport, train, line 18 bus

    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Philadelphia International Airport (PHL)plane plane RDU - PHL
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    4. Take the bus from AMTRAK ETown to W. Chestnut & Water St.bus bus
    8h 54m

  6. Train to Piedmont Triad International Airport, fly to Philadelphia International Airport, train

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Philadelphia International Airport (PHL)plane plane GSO - PHL
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    8h 58m
    $167–565

Durham to Lancaster by bus and train

Calendar4Weekly Services
Duration11h 51mAverage Duration
Ticket$71Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Lancaster.ExpandLaunch map view
  • Distance: 413.3 mi
  • Duration: 11h 51m

What companies run services between Durham, NC, USA and Lancaster, PA, USA?

You can take a bus from Durham to W. Chestnut & Water St. via Washington Union Station, Harrisburg Bus Station, Harrisburg, Elizabethtown Amtrak Station, and AMTRAK ETown in around 11h 51m. Alternatively, you can take a train from Durham Amtrak Station to W. Chestnut & Water St. via 30th Street Station, Elizabethtown Amtrak Station, and AMTRAK ETown in around 13h 59m.

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