Rome2Rio

How to get fromDurham to Lexingtonby plane, car, bus, or train

Find Transport to Lexington

See all options

There are 10 ways to get from Durham to Lexington by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Louisville International Airport, drive

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 27m
    $138–726

  2. Fly Raleigh-Durham International Airport to Blue Grass Airport

    cheapest
    1. Fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX)plane plane RDU - LEX
    8h 33m
    $66–378

  3. Bus, drive

    1. Take the bus from Durham to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Louisville Bus Stationbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    21h 23m
    $132–229

  4. Train, bus, drive via Toledo

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Toledotrain train
    3. Take the bus from Toledo Bus Stop to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    31h 58m
    $265–604

  5. Drive  425.4 mi

    1. Drive from Durham to Lexingtoncar car 425.4 mi
    8h 23m
    $78–113

  6. Fly Raleigh-Durham International Airport to Covington, drive

    1. Fly from Raleigh-Durham International Airport (RDU) to Covington (CVG)plane plane RDU - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    5h 30m
    $114–678

  7. Train to Piedmont Triad International Airport, fly to Blue Grass Airport

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Blue Grass Airport (LEX)plane plane GSO - LEX
    8h 24m
    $110–493

  8. Train to Charlotte Douglas International Airport, fly to Louisville International Airport, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    7h 35m
    $146–711

  9. Train to Charlotte Douglas International Airport, fly to Blue Grass Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    8h 30m
    $94–432

  10. Train, bus, drive

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the bus from Greensboro to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to Louisvillebus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    21h 54m
    $93–214

Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF) flights

Calendar68Weekly Planes
Duration3h 52mAverage Duration
Ticket$123Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Durham to Lexington.ExpandLaunch map view
  • Distance: 511.4 mi
  • Duration: 5h 27m

What companies run services between Durham, NC, USA and Lexington, KY, USA?

Delta and American Airlines fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX) hourly.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound