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How to get fromDurham to Louisvilleby bus, plane, bus (Flixbus, Greyhound, Amtrak), train, or car

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There are 8 ways to get from Durham to Louisville by bus, plane, bus (Flixbus, Greyhound, Amtrak), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    4h 59m
    $185–418

  2. Bus

    cheapest
    1. Take the bus from Columbia & Rosemary to Coble Transportation Centerbus bus 4
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    20h 22m
    $64–158

  3. Bus via Atlanta

    1. Take the bus from Durham to Atlanta Downtownbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    16h 34m
    $127–224

  4. Train, bus (Amtrak)

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    25h 14m
    $295–600

  5. Drive 497.5 mi

    1. Drive from Durham to Louisvillecar car 497.5 mi
    9h 28m
    $91–132

  6. Train to Piedmont Triad International Airport, fly

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF)plane plane GSO - SDF
    6h 52m
    $149–678

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    7h 24m
    $140–654

  8. Train, bus via Arlington (Amtrak)

    1. Take the train from Durham Amtrak Station to Alexandriatrain train
    2. Take the train from Alexandria to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 54m
    $359–725

Durham to Louisville by bus and subway

Calendar5Weekly Services
Duration16h 34mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from Durham to Louisville.ExpandLaunch map view
  • Distance: 438.1 mi
  • Duration: 4h 59m

What companies run services between Durham, NC, USA and Louisville, KY, USA?

You can take a bus from Durham to Louisville, KY via Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Nashville in around 16h 34m.

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