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How to get fromDurham to Louisvilleby bus, plane, bus (Flixbus, Greyhound), train, or car

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There are 9 ways to get from Durham to Louisville by bus, plane, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly to Louisville International Airport

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    5h 9m
    $125–708

  2. Bus

    cheapest
    1. Take the bus from Columbia & Rosemary to Coble Transportation Centerbus bus 4
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to Louisvillebus bus
    20h 57m
    $64–188

  3. Bus via Atlanta

    1. Take the bus from Durham to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to Louisville Bus Stationbus bus Greyhound US0105 / ...
    16h 49m
    $120–197

  4. Train, bus

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    24h 39m
    $225–537

  5. Drive  497.5 mi

    1. Drive from Durham to Louisvillecar car 497.5 mi
    9h 30m
    $91–132

  6. Train to Piedmont Triad International Airport, fly to Louisville International Airport

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF)plane plane GSO - SDF
    7h 9m
    $154–825

  7. Train to Charlotte Douglas International Airport, fly to Louisville International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    7h 17m
    $133–694

  8. Train to Charlotte Douglas International Airport, fly to Blue Grass Airport, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 25m
    $105–450

  9. Bus, train

    1. Take the bus from Durham Station to Union Station - Bus Platform Abus bus Drx
    2. Take the train from Raleigh Union Station to Toledotrain train
    3. Take the bus from Toledo Bus Stop to Louisville Bus Stationbus bus
    28h 36m
    $248–568

Durham to Louisville by bus and subway

Calendar4Weekly Services
Duration16h 49mAverage Duration
Ticket$120Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Louisville.ExpandLaunch map view
  • Distance: 438.1 mi
  • Duration: 5h 9m

What companies run services between Durham, NC, USA and Louisville, KY, USA?

You can take a bus from Durham to Louisville Bus Station via Atlanta Downtown, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 16h 49m.

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