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How to get fromDurham to Louisvilleby bus, plane, bus (Flixbus, Greyhound, Amtrak), train, car, or bus (Greyhound, Flixbus, Amtrak)

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There are 9 ways to get from Durham to Louisville by bus, plane, bus (Flixbus, Greyhound, Amtrak), train, car, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly to Louisville International Airport

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    5h 9m
    $115–708

  2. Drive  497.5 mi

    cheapest
    1. Drive from Durham to Louisvillecar car 497.5 mi
    9h 30m
    $91–132

  3. Bus via Atlanta

    1. Take the bus from Durham to Atlanta Downtownbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    16h 34m
    $129–212

  4. Train, bus (Amtrak)

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    24h 44m
    $472–791

  5. Train to Piedmont Triad International Airport, fly to Louisville International Airport

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF)plane plane GSO - SDF
    7h
    $181–889

  6. Train to Charlotte Douglas International Airport, fly to Louisville International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    7h 20m
    $183–783

  7. Train to Charlotte Douglas International Airport, fly to Blue Grass Airport, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 16m
    $150–499

  8. Bus

    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Take the bus from Greensboro to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    20h 55m
    $106–208

  9. Train, bus via Arlington (Amtrak)

    1. Take the train from Durham Amtrak Station to Alexandriatrain train
    2. Take the train from Alexandria to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 24m
    $590–918

Durham to Louisville by bus and subway

Calendar4Weekly Services
Duration16h 34mAverage Duration
Ticket$129Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Louisville.ExpandLaunch map view
  • Distance: 438.1 mi
  • Duration: 5h 9m

What companies run services between Durham, NC, USA and Louisville, KY, USA?

You can take a bus from Durham to Louisville, KY via Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Nashville in around 16h 34m.

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Bus operators

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