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How to get fromDurham to Orangeburgby bus (Greyhound, Flixbus), train, bus, train (Amtrak), car, bus (Greyhound), plane, or taxi

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There are 9 ways to get from Durham to Orangeburg by bus (Greyhound, Flixbus), train, bus, train (Amtrak), car, bus (Greyhound), plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Charlotte

    best
    1. Take the bus from Durham to Charlotte Bus Stationbus bus Greyhound US0670
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus FlixBus 2433
    6h 13m
    $52–88

  2. Drive  239.4 mi

    cheapest
    1. Drive from Durham to Orangeburgcar car 239.4 mi
    4h 47m
    $44–64

  3. Train, bus

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train Piedmont / ...
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus FlixBus 2433
    6h 47m
    $114–180

  4. Train (Amtrak)

    1. Take the train from Cary to Denmark Amtrak Stationtrain train Floridian
    7h 10m
    $205–305

  5. Bus

    1. Take the bus from Durham to Camdenbus bus Nyc
    2. Take the bus from Camden to Orangeburgbus bus Greyhound US0644S
    8h 47m
    $64–94

  6. Fly Raleigh-Durham International Airport to Columbia, taxi

    1. Fly from Raleigh-Durham International Airport (RDU) to Columbia (CAE)plane plane RDU - CAE
    2. Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi taxi
    6h 3m
    $169–486

  7. Train to Charlotte Douglas International Airport, fly to Columbia, taxi

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Columbia (CAE)plane plane CLT - CAE
    3. Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi taxi
    6h 23m
    $242–590

  8. Train to Charlotte Douglas International Airport, fly to Charleston International Airport, drive

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Charleston International Airport (CHS)plane plane CLT - CHS
    3. Drive from Charleston-Airport-CHS to Orangeburgcar car
    7h 2m
    $149–549

  9. Fly Raleigh-Durham International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Raleigh-Durham International Airport (RDU) to Charlotte Douglas International Airport (CLT)plane plane RDU - CLT
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    7h 46m
    $102–562

Raleigh-Durham International Airport (RDU) to Columbia (CAE) flights

Calendar114Weekly Planes
Duration3h 54mAverage Duration
Ticket$47Cheapest Price
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Map of how to get from Durham to Orangeburg.ExpandLaunch map view
  • Distance: 281 mi
  • Duration: 6h 13m

What companies run services between Durham, NC, USA and Orangeburg, SC, USA?

You can take a bus from Durham to Orangeburg via Charlotte Bus Station and Orangeburg in around 6h 13m. Alternatively, Amtrak operates a train from Cary to Denmark Amtrak Station once daily. Tickets cost $130–210 and the journey takes 5h 14m.

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