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How to get fromDurham to Syracuseby bus, plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

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There are 10 ways to get from Durham to Syracuse by bus, plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly to Syracuse Hancock International Airport

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Syracuse Hancock International Airport (SYR)plane plane RDU - SYR
    5h 42m
    $125–764

  2. Fly Raleigh-Durham International Airport to Ithaca Tompkins Regional Airport, bus

    cheapest
    1. Fly from Raleigh-Durham International Airport (RDU) to Ithaca Tompkins Regional Airport (ITH)plane plane RDU - ITH
    2. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    9h 38m
    $78–402

  3. Bus (Flixbus)

    1. Take the bus from Durham to New York Midtownbus bus FlixBus N2471 / ...
    2. Take the bus from New York Midtown to Syracuse Bus Stationbus bus FlixBus 2685 / ...
    16h 19m
    $130–220

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Carolinian
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Syracuse Regional Transportation Centertrain train Empire Service / ...
    17h 47m
    $267–564

  5. Drive 616.3 mi

    1. Drive from Durham to Syracusecar car 616.3 mi
    11h 5m
    $113–163

  6. Fly Raleigh-Durham International Airport to Rochester, train

    1. Fly from Raleigh-Durham International Airport (RDU) to Rochester (ROC)plane plane RDU - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    6h 25m
    $163–1,098

  7. Fly Raleigh-Durham International Airport to Buffalo Niagara International Airport, bus

    1. Fly from Raleigh-Durham International Airport (RDU) to Buffalo Niagara International Airport (BUF)plane plane RDU - BUF
    2. Take the bus from Buffalo Niagara International Airport to Syracuse Bus Stationbus bus
    7h 29m
    $151–516

  8. Train to Charlotte Douglas International Airport, fly to Syracuse Hancock International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Syracuse Hancock International Airport (SYR)plane plane CLT - SYR
    8h 26m
    $204–960

  9. Train via Albany

    1. Take the train from Durham Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Albany-Rensselaer Amtrak Stationtrain train
    3. Take the train from Albany-Rensselaer Amtrak Station to Syracuse Regional Transportation Centertrain train
    18h 20m
    $262–649

  10. Bus via New York

    1. Take the bus from Durham to Port Authority Bus Terminalbus bus Greyhound US0670
    2. Take the bus from Port Authority Bus Terminal to Syracuse Bus Stationbus bus Greyhound US0205 / ...
    18h 24m
    $124–319

Durham to Syracuse by bus (Flixbus)

Calendar22Weekly Buses
Duration16h 19mAverage Duration
Ticket$130Cheapest Price
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Questions & Answers

Map of how to get from Durham to Syracuse.ExpandLaunch map view
  • Distance: 548.5 mi
  • Duration: 5h 42m

What companies run services between Durham, NC, USA and Syracuse, NY, USA?

You can take a bus from Durham to Syracuse Bus Station via New York Midtown in around 16h 19m. Alternatively, you can take a train from Durham Amtrak Station to Syracuse Regional Transportation Center via Ny Moynihan Train Hall At Penn Station in around 17h 47m.

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