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How to get fromEast Setauket to Buffaloby train, plane, bus, or car

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There are 8 ways to get from East Setauket to Buffalo by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Stony Brook to Jamaicatrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    5h 44m
    $100–547

  2. Drive 411.9 mi

    cheapest
    1. Drive from East Setauket to Buffalocar car 411.9 mi
    8h 24m
    $76–109

  3. Train

    1. Take the train from Ronkonkoma to New York Penn Stationtrain train Ronkonkoma Branch
    2. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    11h 52m
    $125–322

  4. Train, bus

    1. Take the train from Ronkonkoma to New York Penn Stationtrain train Ronkonkoma Branch
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus N2686 / ...
    11h 53m
    $85–152

  5. Train, train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Stony Brook to Huntingtontrain train
    2. Take the train from Huntington to New York Penn Stationtrain train
    3. Take the train from New York Penn Station to Newark Airport Railroad Stationtrain train
    4. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    6h 55m
    $112–582

  6. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Stony Brook to Jamaicatrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    7h 11m
    $117–719

  7. Train to John F. Kennedy International Airport, fly to Rochester, bus

    1. Take the train from Stony Brook to Jamaicatrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Rochester (ROC)plane plane JFK - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 28m
    $122–543

  8. Bus

    1. Take the bus from Manorville to 86 St & Central Park Westbus bus Sag Harbor-Westbound / ...
    2. Take the bus from New York to Buffalobus bus Adt N816 / ...
    13h 32m
    $113–435

East Setauket to Buffalo by bus and train

Calendar7Weekly Services
Duration11h 52mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from East Setauket to Buffalo.ExpandLaunch map view
  • Distance: 364.9 mi
  • Duration: 5h 44m

What companies run services between East Setauket, NY, USA and Buffalo, NY, USA?

You can take a bus from NYS 25A/Main St to Buffalo via Ronkonkoma LIRR, Ronkonkoma, and New York Penn Station in around 11h 52m. Alternatively, you can take a bus from NYS 25A/Main St to Buffalo via Ronkonkoma LIRR, Islip Airport Connection, Manorville, 86 St & Central Park West, 86 St, 42 St-Port Authority Bus Terminal, and New York in around 13h 32m.

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