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How to get fromEcuador to Santa Cruzby plane, bus, car, or shuttle

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There are 6 ways to get from Ecuador to Santa Cruz by plane, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from José Joaquín De Olmedo International Airport

    best
    1. Fly from José Joaquín De Olmedo International Airport (GYE) to Viru Viru International Airport (VVI)plane plane GYE - VVI
    7h 36m
    $414–616

  2. Bus, Tour

    cheapest
    1. Take the bus from Guayaquil to Máncorabus bus
    2. Take the bus from Máncora to Limabus bus
    3. Take the bus from Terminal Ronco to Punobus bus
    4. Take a shuttle bus from Puno to La Pazshuttle bus
    5. Take the bus from La Paz to Santa Cruzbus bus
    3d 17h
    $179–326

  3. Bus, drive

    1. Take the bus from Terminal Terrestre de Guayaquil to Lima Javier Pradobus bus
    2. Take the bus from Lima Terminal Excluciva to Tacnabus bus
    3. Drive from Tacna to El Roble / Dr. Amador Neghmecar car
    4. Take the bus from Terminal Rodoviario de Arica to Huarabus bus
    5. Take the bus from Huara to Iquiquebus bus
    6. Take the bus from Iquique to Santa Cruzbus bus
    2d 19h

  4. Drive 3,717.2 km

    1. Drive from Guayaquil to Santa Cruz de la Sierracar car 3,717.2 km
    2d 4h
    $211–305

  5. Car to Mariscal Sucre International Airport, fly

    1. Drive from Quito to Quito Airportcar car
    2. Fly from Mariscal Sucre International Airport (UIO) to Viru Viru International Airport (VVI)plane plane UIO - VVI
    9h 35m
    $236–776

  6. Bus

    1. Take the bus from Terminal Terrestre de Guayaquil to Tumbesbus bus
    2. Take the bus from Tumbes to Gran Terminal Terrestre Plaza Nortebus bus
    3. Take the bus from Oltursa Lima Terminal to La Pazbus bus
    4. Take the bus from La Paz to Santa Cruzbus bus
    3d
    $204–299

José Joaquín De Olmedo International Airport (GYE) to Viru Viru International Airport (VVI) flights

Calendar23Weekly Planes
Duration9h 44mAverage Duration
Ticket$211Cheapest Price
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Questions & Answers

Map of how to get from Ecuador to Santa Cruz.ExpandLaunch map view
  • Distance: 2,545 km
  • Duration: 7h 36m

What companies run services between Ecuador and Santa Cruz, Bolivia?

LATAM Chile, Copa Airlines, and Avianca - Aerovías del Continente Americano S.A. fly from José Joaquín De Olmedo International Airport (GYE) to Viru Viru International Airport (VVI) 3 times a day. Alternatively, you can take a vehicle from Guayaquil to Santa Cruz de la Sierra via Terminal Terrestre de Guayaquil, Tumbes, Tumbes, Gran Terminal Terrestre Plaza Norte, Oltursa Lima Terminal, La Paz, and Santa Cruz in around 3d.

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