Rome2Rio

How to get fromEdwardsville to Des Moinesby taxi, plane, bus (Greyhound), train, bus, or car

Find Transport to Des Moines

See all options

There are 6 ways to get from Edwardsville to Des Moines by taxi, plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, fly

    best
    1. Take the taxi from Edwardsville to St-Louis-Airport-STLtaxi taxi
    2. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    4h 22m
    $162–535

  2. Drive  327.2 mi

    cheapest
    1. Drive from Edwardsville to Des Moinescar car 327.2 mi
    7h 22m
    $60–87

  3. Bus

    1. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus Greyhound US0180s / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    8h 55m
    $139–203

  4. Train, bus via Kansas City

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the bus from Kansas City Bus Station to Des Moinesbus bus Greyhound US0156
    11h 7m
    $154–273

  5. Train, bus

    1. Take the train from Alton Station to Bloomington-Normaltrain train Texas Eagle / ...
    2. Take the bus from Bloomington-Normal to Des Moinesbus bus Greyhound US0157S
    9h 48m
    $110–191

  6. Train, bus #2

    1. Take the train from Alton Station to Springfieldtrain train
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    3. Take the bus from Galesburg to Des Moinesbus bus
    10h 28m
    $113–181

Lambert–St. Louis International Airport (STL) to Des Moines (DSM) flights

Calendar144Weekly Planes
Duration4h 55mAverage Duration
Ticket$76Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Edwardsville to Des Moines.ExpandLaunch map view
  • Distance: 294.3 mi
  • Duration: 4h 22m

What companies run services between Edwardsville, IL, USA and Des Moines, IA, USA?

You can take a vehicle from Edwardsville to Des Moines via St Louis Bus Station, Kansas City Bus Station, and Kansas City in around 8h 55m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound