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How to get fromEdwardsville to Knoxvilleby taxi, plane, bus (Greyhound), train, bus, or car

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There are 7 ways to get from Edwardsville to Knoxville by taxi, plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Lambert–St. Louis International Airport, fly

    best
    1. Take the taxi from Edwardsville to St-Louis-Airport-STLtaxi taxi
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    4h 51m
    $254–952

  2. Drive 482.1 mi

    cheapest
    1. Drive from Edwardsville to Knoxvillecar car 482.1 mi
    8h 7m
    $88–128

  3. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h 52m
    $397–636

  4. Train, bus

    1. Take the train from Alton Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 20m
    $608–1,114

  5. Taxi to Midamerica St. Louis Airport, fly

    1. Take the taxi from Edwardsville to Midamerica St. Louis Airport (BLV)taxi taxi
    2. Fly from Midamerica St. Louis Airport (BLV) to Mcghee Tyson Airport (TYS)plane plane BLV - TYS
    6h 35m
    $288–944

  6. Train, bus via Ossining

    1. Take the train from Alton Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 57m
    $563–1,041

  7. Train, bus via Indianapolis

    1. Take the train from Alton Station to Bloomington-Normaltrain train
    2. Take the bus from Bloomington to Indianapolisbus bus
    3. Take the bus from Indianapolis to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    41h 18m

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Edwardsville to Knoxville.ExpandLaunch map view
  • Distance: 446.2 mi
  • Duration: 4h 51m

What companies run services between Edwardsville, IL, USA and Knoxville, TN, USA?

You can take a vehicle from Edwardsville to Knoxville via St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 38h 52m.

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