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How to get fromEffingham to Buffaloby bus (Greyhound), train (Amtrak), car, train, plane, bus (Greyhound, Flixbus), or bus

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There are 8 ways to get from Effingham to Buffalo by bus (Greyhound), train (Amtrak), car, train, plane, bus (Greyhound, Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Indianapolis

    best
    1. Take the bus from Effingham to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Toledobus bus
    3. Take the bus from Toledo to Clevelandbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    14h 30m
    $72–205

  2. Train (Amtrak)

    1. Take the train from Effingham Station to Chicago Union Stationtrain train Saluki / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 35m
    $171–565

  3. Drive  636.5 mi

    1. Drive from Effingham to Buffalocar car 636.5 mi
    10h 58m
    $117–168

  4. Train to University Of Illinois Willard Airport, fly

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Buffalo Niagara International Airport (BUF)plane plane CMI - BUF
    9h 16m
    $132–615

  5. Bus

    1. Take the bus from Effingham to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Buffalobus bus FlixBus 2526
    16h 29m
    $103–158

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Effingham Station to Homewoodtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    8h 16m
    $211–424

  7. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Effingham Station to Homewoodtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    8h 41m
    $221–414

  8. Train, bus to Decatur Airport, fly

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Decatur Downtown Transportation Centerbus bus
    3. Fly from Decatur Airport (DEC) to Buffalo Niagara International Airport (BUF)plane plane DEC - BUF
    11h 15m
    $135–621

Effingham to Buffalo by bus

Calendar14Weekly Buses
Duration14h 30mAverage Duration
Ticket$72Cheapest Price
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Comparing Your Travel Options

Map of how to get from Effingham to Buffalo.ExpandLaunch map view
  • Distance: 666.7 mi
  • Duration: 14h 30m

What companies run services between Effingham, IL, USA and Buffalo, NY, USA?

You can take a bus from Effingham to Buffalo, NY via Indianapolis, IN, Toledo, and Cleveland, OH in around 14h 30m. Alternatively, you can take a train from Effingham Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 16h 35m.

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