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How to get fromEffingham to Florenceby bus, plane, train, train (Amtrak), car, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 6 ways to get from Effingham to Florence by bus, plane, train, train (Amtrak), car, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Florence Regional Airport (FLO)plane plane STL - FLO
    8h 32m
    $117–504

  2. Train, bus

    1. Take the train from Effingham Station to Carbondaletrain train
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    18h 23m
    $185–288

  3. Train (Amtrak)

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    34h 5m
    $745–1,264

  4. Drive  734.4 mi

    1. Drive from Effingham to Florencecar car 734.4 mi
    14h 56m
    $126–182

  5. Bus

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    21h 45m
    $164–273

  6. Bus via Columbus

    1. Take the bus from Effingham to Columbusbus bus
    2. Take the bus from Columbus to Charlottebus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    24h 25m
    $128–225

Effingham to Florence by train and bus

Calendar10Weekly Services
Duration18h 23mAverage Duration
Ticket$185Cheapest Price
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Comparing Your Travel Options

Map of how to get from Effingham to Florence.ExpandLaunch map view
  • Distance: 785.8 mi
  • Duration: 8h 32m

What companies run services between Effingham, IL, USA and Florence, SC, USA?

You can take a train from Effingham Station to Florence Station via Chicago Union Station, Raleigh Union Station, and Selma Station in around 34h 5m. Alternatively, you can take a bus from Effingham to Florence Bus Station via St Louis Bus Station and Atlanta Bus Station in around 21h 45m.

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Bus operators

Want to know more about travelling around United States

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