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How to get fromEffingham to Knoxvilleby bus, plane, bus (Greyhound), train, or car

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There are 8 ways to get from Effingham to Knoxville by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    6h 35m
    $204–950

  2. Drive  416 mi

    cheapest
    1. Drive from Effingham to Knoxvillecar car 416 mi
    8h 21m
    $76–110

  3. Bus

    1. Take the bus from Effingham to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    36h 17m
    $333–503

  4. Train, bus

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 14m
    $441–846

  5. Train to University Of Illinois Willard Airport, fly to Mcghee Tyson Airport

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Mcghee Tyson Airport (TYS)plane plane CMI - TYS
    8h 2m
    $232–934

  6. Bus to Lambert–St. Louis International Airport, fly to Nashville, drive

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 27m
    $179–830

  7. Train, bus to Decatur Airport, fly to Mcghee Tyson Airport

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Decatur Downtown Transportation Centerbus bus
    3. Fly from Decatur Airport (DEC) to Mcghee Tyson Airport (TYS)plane plane DEC - TYS
    11h 1m
    $235–941

  8. Bus, train

    1. Take the bus from Effingham to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 21m
    $455–841

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar133Weekly Planes
Duration4h 26mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Effingham to Knoxville.ExpandLaunch map view
  • Distance: 532.3 mi
  • Duration: 6h 35m

What companies run services between Effingham, IL, USA and Knoxville, TN, USA?

You can take a bus from Effingham to Knoxville via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 36h 17m.

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