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How to get fromEffingham to Mayo Clinicby train, plane, bus, car, or bus (Greyhound)

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There are 10 ways to get from Effingham to Mayo Clinic by train, plane, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to University Of Illinois Willard Airport, fly to Rochester

    best
    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane plane CMI - RST
    7h 24m
    $113–462

  2. Drive  470.2 mi

    cheapest
    1. Drive from Effingham to Mayo Cliniccar car 470.2 mi
    9h 39m
    $81–117

  3. Bus

    1. Take the bus from Lupita's Grocery - Effingham to Water & Chicago - Circle Kbus bus Milwaukee
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    12h 33m
    $133–180

  4. Train, bus

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    14h 53m
    $358–558

  5. Bus to Lambert–St. Louis International Airport, fly to Rochester

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    8h 42m
    $93–500

  6. Bus to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 13m
    $157–630

  7. Train to Chicago O'Hare International Airport, fly to Rochester

    1. Take the train from Effingham Station to Homewoodtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    9h
    $139–459

  8. Bus to Indianapolis, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Effingham to Indianapolis Union Stationbus bus
    2. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 55m
    $181–703

  9. Bus via Chicago

    1. Take the bus from Effingham to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 11m
    $114–187

  10. Train, bus via Madison

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 35m
    $185–298

Effingham to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration14h 53mAverage Duration
Ticket$358Cheapest Price
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Comparing Your Travel Options

Map of how to get from Effingham to Mayo Clinic.ExpandLaunch map view
  • Distance: 431.3 mi
  • Duration: 7h 24m

What companies run services between Effingham, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Lupita's Grocery - Effingham to Mayo Clinic via Water & Chicago - Circle K, Milwaukee, and Rochester in around 12h 33m.

Airlines
Train operators
Bus operators

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