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How to get fromEffingham to Mayo Clinicby bus, train, car, plane, or bus (Greyhound)

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There are 10 ways to get from Effingham to Mayo Clinic by bus, train, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Lupita's Grocery - Effingham to Water & Chicago - Circle Kbus bus Milwaukee
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    12h 34m
    $137–269

  2. Drive 470.1 mi

    cheapest
    1. Drive from Effingham to Mayo Cliniccar car 470.1 mi
    9h 39m
    $86–124

  3. Train, bus

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    15h
    $223–440

  4. Train to University Of Illinois Willard Airport, fly to Rochester

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane plane CMI - RST
    7h 33m
    $96–389

  5. Bus via Chicago

    1. Take the bus from Effingham to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 12m
    $108–193

  6. Train, bus via Madison

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 35m
    $140–260

  7. Bus to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 41m
    $451–1,035

  8. Train to Chicago O'Hare International Airport, fly to Rochester

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    8h 42m
    $112–425

  9. Bus to Indianapolis, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Effingham to Indianapolis Union Stationbus bus
    2. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 23m
    $585–1,213

  10. Train, bus to Abraham Lincoln Capital Airport, fly to Rochester

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Springfield SMTD Transfer Centerbus bus
    3. Fly from Abraham Lincoln Capital Airport (SPI) to Rochester (RST)plane plane SPI - RST
    9h 59m
    $105–418

Effingham to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration15hAverage Duration
Ticket$223Cheapest Price
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Questions & Answers

Map of how to get from Effingham to Mayo Clinic.ExpandLaunch map view
  • Distance: 580.9 mi
  • Duration: 12h 34m

What companies run services between Effingham, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Lupita's Grocery - Effingham to Mayo Clinic via Water & Chicago - Circle K, Milwaukee, and Rochester in around 12h 34m.

Airlines
Train operators
Bus operators

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