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How to get fromEffingham to Mayo Clinicby bus, train, car, plane, or bus (Greyhound)

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There are 9 ways to get from Effingham to Mayo Clinic by bus, train, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Lupita's Grocery - Effingham to Water & Chicago - Circle Kbus bus Milwaukee
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    12h 35m
    $133–180

  2. Drive  470.1 mi

    cheapest
    1. Drive from Effingham to Mayo Cliniccar car 470.1 mi
    9h 39m
    $86–124

  3. Train, bus

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    14h 55m
    $177–396

  4. Train to University Of Illinois Willard Airport, fly to Rochester

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane plane CMI - RST
    8h 29m
    $92–444

  5. Bus via Chicago

    1. Take the bus from Effingham to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 13m
    $108–182

  6. Train, bus via Madison

    1. Take the train from Effingham Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 37m
    $124–246

  7. Bus to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 51m
    $451–1,030

  8. Train to Chicago O'Hare International Airport, fly to Rochester

    1. Take the train from Effingham Station to Homewoodtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    9h
    $90–434

  9. Train, bus to Abraham Lincoln Capital Airport, fly to Rochester

    1. Take the train from Effingham Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Springfield SMTD Transfer Centerbus bus
    3. Fly from Abraham Lincoln Capital Airport (SPI) to Rochester (RST)plane plane SPI - RST
    10h 58m
    $100–469

Effingham to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration14h 55mAverage Duration
Ticket$177Cheapest Price
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Comparing Your Travel Options

Map of how to get from Effingham to Mayo Clinic.ExpandLaunch map view
  • Distance: 579.4 mi
  • Duration: 12h 35m

What companies run services between Effingham, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Lupita's Grocery - Effingham to Mayo Clinic via Water & Chicago - Circle K, Milwaukee, and Rochester in around 12h 35m.

Airlines
Train operators
Bus operators

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