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How to get fromEffingham to Panama Cityby bus, plane, or car

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There are 7 ways to get from Effingham to Panama City by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    5h 37m
    $173–591

  2. Bus to Lambert–St. Louis International Airport, fly to Pensacola International Airport, drive

    cheapest
    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    3. Drive from Pensacola-Airport-PNS to Panama Citycar car
    7h 37m
    $112–480

  3. Bus, drive

    1. Take the bus from Effingham to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Orangebus bus
    4. Take the bus from Orange to Crestviewbus bus
    5. Drive from Crestview to Front Beach Rd. & Back Beach Rd.car car
    43h 52m
    $296–521

  4. Drive 714 mi

    1. Drive from Effingham to Panama Citycar car 714 mi
    13h 12m
    $131–189

  5. Bus to Lambert–St. Louis International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    6h 38m
    $115–519

  6. Bus to Indianapolis, fly to Northwest Florida Beaches International Airport

    1. Take the bus from Effingham to Indianapolis Union Stationbus bus
    2. Fly from Indianapolis (IND) to Northwest Florida Beaches International Airport (ECP)plane plane IND - ECP
    7h 19m
    $181–598

  7. Bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Effingham to St Louis Bus Stationbus bus
    2. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    7h
    $118–437

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration2h 57mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Effingham to Panama City.ExpandLaunch map view
  • Distance: 772.5 mi
  • Duration: 5h 37m

What companies run services between Effingham, IL, USA and Panama City, FL, USA?

There is no direct connection from Effingham to Panama City. However, you can take the bus to St Louis Bus Station, walk to CIVIC CENTER station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Northwest Florida Beaches International Airport (ECP), then take the taxi to Panama City. Alternatively, you can take a bus from Effingham to 11th St. & Harrison Ave. via Indianapolis Union Station, Montgomery Intermodal Center, Orange, Crestview, Front Beach Rd. & Back Beach Rd., and Gulf Coast State College in around 43h 52m.

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