There are 7 ways to get from Enola to Chicago by plane, train (Amtrak), bus (Flixbus), car, bus, train, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Harrisburg International Airport to Chicago O'Hare International Airport
best- Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane MDT - ORD
5h 20m$54–299Train (Amtrak)
- Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain Pennsylvanian
- Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain Floridian
17h 28m$390–622Bus (Flixbus)
- Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus FlixBus N2640 / ...
17h 43m$120–192Drive 652.6 mi
- Drive from Enola to Chicagocar 652.6 mi
10h 42m$120–172Bus to Penn State University Park Airport, fly to Chicago O'Hare International Airport
- Take the bus from Harrisburg Bus Station to State College Regional Airportbus
- Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane SCE - ORD
6h 46m$61–309Train to Philadelphia International Airport, fly to Chicago Midway International Airport
- Take the train from Harrisburg to 30th Street Stationtrain
- Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane PHL - MDW
7h 24m$209–471Bus via Baltimore (Greyhound)
- Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus Greyhound US0430
- Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus Greyhound US0164
24h 58m$156–242
Enola to Chicago by bus and train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Enola to Chicago is to drive which costs $110 - $180 and takes 10h 42m.
The fastest way to get from Enola to Chicago is to fly which takes 5h 20m and costs $50 - $300.
No, there is no direct bus from Enola to Chicago station. However, there are services departing from Enola Dr & Cumberland Rd and arriving at Chicago Bus Station via Harrisburg Bus Station. The journey, including transfers, takes approximately 17h 43m.
No, there is no direct train from Enola to Chicago station. However, there are services departing from Harrisburg and arriving at Chicago Union Station via Pittsburgh Amtrak Station. The journey, including transfers, takes approximately 17h 28m.
The distance between Enola and Chicago is 630 miles. The road distance is 656.4 miles.
The best way to get from Enola to Chicago without a car is to train which takes 17h 28m and costs $390 - $650.
It takes approximately 5h 20m to get from Enola to Chicago, including transfers.
Enola to Chicago bus services, operated by Flixbus USA, depart from Harrisburg Bus Station.
Enola to Chicago train services, operated by Amtrak, depart from Harrisburg station.
The best way to get from Enola to Chicago is to fly which takes 5h 20m and costs $50 - $300. Alternatively, you can train, which costs $390 - $650 and takes 17h 28m, you could also bus, which costs $120 - $200 and takes 17h 43m.
What companies run services between Enola, PA, USA and Chicago, IL, USA?
American Airlines, United Airlines, and Delta fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a bus from Enola Dr & Cumberland Rd to Chicago Union Station via Aberdeen St & Strawberry St, Harrisburg, and Pittsburgh Amtrak Station in around 17h 28m.
- Website
- southwest.com
Flights from Philadelphia International Airport to Chicago Midway International Airport
- Ave. Duration
- 2h 9m
- When
- Every day
- Estimated price
- $100–600
Flights from Philadelphia International Airport to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 3h 50m
- When
- Monday, Thursday, and Friday
- Estimated price
- $100–600
- Website
- aa.com
Flights from Harrisburg International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 23m
- When
- Every day
- Estimated price
- $50–290
Flights from Harrisburg International Airport to Chicago O'Hare International Airport via Philadelphia International Airport
- Ave. Duration
- 4h 24m
- When
- Thursday and Friday
- Estimated price
- $55–320
Flights from Penn State University Park Airport to Chicago O'Hare International Airport via Philadelphia International Airport
- Ave. Duration
- 4h 57m
- When
- Tuesday to Saturday
- Estimated price
- $60–330
- Website
- united.com
Flights from Harrisburg International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 19m
- When
- Every day
- Estimated price
- $50–290
Flights from Penn State University Park Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $45–280
Flights from Penn State University Park Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $55–310
- Website
- delta.com
Flights from Harrisburg International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $50–290
Flights from Philadelphia International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 59m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Harrisburg to Pittsburgh Amtrak Station
- Ave. Duration
- 5h 29m
- Frequency
- Once daily
- Estimated price
- $130–210
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $260–410
- Website
- Amtrak
Train from Harrisburg to 30th Street Station
- Ave. Duration
- 1h 44m
- Frequency
- Every 2 hours
- Estimated price
- $55–90
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Harrisburg Bus Station to Chicago Bus Station
- Ave. Duration
- 16h 30m
- Frequency
- Once daily
- Estimated price
- $120–190
- Schedules at
- Flixbus USA
Bus from Harrisburg Bus Station to State College Regional Airport
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $14–22
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Harrisburg Bus Station to Baltimore Downtown Bus Station
- Ave. Duration
- 4h 5m
- Frequency
- 4 times a week
- Estimated price
- $26–40
- Website
- Greyhound
Bus from Baltimore Downtown Bus Station to Chicago Bus Station
- Ave. Duration
- 18h 40m
- Frequency
- Twice daily
- Estimated price
- $130–200
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
Enola to Chicago bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Chicago is 1h behind Enola. It is currently 12:04 PM in Enola and 11:04 AM in Chicago.
Enola to Chicago train services, operated by Amtrak, arrive at Pittsburgh Amtrak Station.
Yes, the driving distance between Enola to Chicago is 656 miles. It takes approximately 10h 42m to drive from Enola to Chicago.
There are 1294+ hotels available in Chicago.








