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How to get fromEnschede to Sienaby train, plane, train (Trenitalia), bus, night train, train (Eurostar, Trenitalia), car, or car train

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There are 15 ways to get from Enschede to Siena by train, plane, train (Trenitalia), bus, night train, train (Eurostar, Trenitalia), car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Amsterdam Airport Schiphol, fly to Florence Peretola Airport, train

    best
    1. Take the train from Enschede to Schiphol Airport Train Stationtrain train
    2. Fly from Amsterdam Airport Schiphol (AMS) to Florence Peretola Airport (FLR)plane plane AMS - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 45m
    €132–330

  2. Train, train to Eindhoven Airport, fly to Pisa International Airport

    cheapest
    1. Take the train from Enschede to Utrecht Centraaltrain train
    2. Take the train from Utrecht Centraal to Eindhoven Centraaltrain train
    3. Fly from Eindhoven Airport (EIN) to Pisa International Airport (PSA)plane plane EIN - PSA
    4. Take the train from Pisa Centrale to Empolitrain train
    5. Take the train from Empoli to Sienatrain train
    9h 27m
    €102–377

  3. Train via Basel

    1. Take the train from Enschede to Münster Hauptbahnhoftrain train
    2. Take the train from Münster Hauptbahnhof to Basel SBBtrain train 43
    3. Take the train from Basel SBB to Luganotrain train Ec
    4. Take the train from Lugano to Milano Centraletrain train
    5. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    6. Take the train from Firenze S.M.N. to Sienatrain train Re
    18h 26m
    €205–1,037

  4. Bus

    1. Take the bus from Enschede to Dortmund central bus stationbus bus
    2. Take the bus from Dortmund Hbf to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    22h 44m

  5. Train, night train, bus

    1. Take the train from Enschede to Dortmund Hbftrain train
    2. Take the train from Dortmund Hbf to Hauptbahnhoftrain train 47 / ...
    3. Take the nighttrain from Stuttgart Hbf to Verona Porta Nuovanighttrain night train Nj
    4. Take the train from Verona Porta Nuova to Firenze S.M.N.train train Fr
    5. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    23h 52m
    €172–620

  6. Train, train to Düsseldorf International Airport, fly to Florence Peretola Airport

    1. Take the train from Enschede to Duelmentrain train
    2. Take the train from Dülmen, Bahnhof to D-Flughafen Bftrain train
    3. Fly from Düsseldorf International Airport (DUS) to Florence Peretola Airport (FLR)plane plane DUS - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 31m
    €138–310

  7. Train to Münster Osnabrück International Airport, fly to Florence Peretola Airport, train

    1. Take the train from Enschede to Münster Hauptbahnhoftrain train
    2. Fly from Münster Osnabrück International Airport (FMO) to Florence Peretola Airport (FLR)plane plane FMO - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    10h 14m
    €149–438

  8. Train to Amsterdam Airport Schiphol, fly to Pisa International Airport, train

    1. Take the train from Enschede to Schiphol Airport Train Stationtrain train
    2. Fly from Amsterdam Airport Schiphol (AMS) to Pisa International Airport (PSA)plane plane AMS - PSA
    3. Take the train from Pisa Centrale to Empolitrain train
    4. Take the train from Empoli to Sienatrain train
    8h 38m
    €131–339

  9. Train to Amsterdam Airport Schiphol, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Enschede to Schiphol Airport Train Stationtrain train
    2. Fly from Amsterdam Airport Schiphol (AMS) to Bologna Guglielmo Marconi Airport (BLQ)plane plane AMS - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 16m
    €129–345

  10. Train, train to Düsseldorf International Airport, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Enschede to Duelmentrain train
    2. Take the train from Dülmen, Bahnhof to D-Flughafen Bftrain train
    3. Fly from Düsseldorf International Airport (DUS) to Bologna Guglielmo Marconi Airport (BLQ)plane plane DUS - BLQ
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    10h 6m
    €130–385

  11. Train, train to Eindhoven Airport, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Enschede to Utrecht Centraaltrain train
    2. Take the train from Utrecht Centraal to Eindhoven Centraaltrain train
    3. Fly from Eindhoven Airport (EIN) to Bologna Guglielmo Marconi Airport (BLQ)plane plane EIN - BLQ
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    10h 5m
    €115–373

  12. Train

    1. Take the train from Enschede to Rotterdam Centraaltrain train
    2. Take the train from Rotterdam Centraal to Chambery Challes Les Eauxtrain train
    3. Take the train from Chambery Challes Les Eaux to Milano Centraletrain train Fr
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    18h 41m
    €373–683

  13. Train, bus

    1. Take the train from Enschede to Dortmund Hbftrain train
    2. Take the bus from Dortmund central bus station to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    24h 38m
    €117–225

  14. Drive 1,341.7 km

    1. Drive from Enschede to Sienacar car 1,341.7 km
    12h 35m
    €239–345

  15. Drive, car train

    1. Drive from Enschede to Fuldacar car
    2. Take the cartrain from Fulda to München Ostcartrain train
    3. Drive from München Ost to Sienacar car
    15h 26m
    €254–355

Enschede to Siena by train

Calendar76Weekly Trains
Duration18h 26mAverage Duration
Ticket€205Cheapest Price
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Questions & Answers

Map of how to get from Enschede to Siena.ExpandLaunch map view
  • Distance: 1,329.8 km
  • Duration: 8h 45m

What companies run services between Enschede, Netherlands and Siena, Italy?

You can take a train from Enschede to Siena via Münster Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 18h 26m. Alternatively, you can take a bus from Enschede to Siena via Dortmund central bus station, Dortmund Hbf, and Florence Villa Constanza Bus Station in around 22h 44m.

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