Rome2Rio

How to get fromErie to Knoxvilleby plane, train, bus, car, or bus (Greyhound, Flixbus)

Find Transport to Knoxville

See all options

There are 8 ways to get from Erie to Knoxville by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Erie International Airport to Mcghee Tyson Airport

    best
    1. Fly from Erie International Airport (ERI) to Mcghee Tyson Airport (TYS)plane plane ERI - TYS
    6h 30m
    $227–1,072

  2. Fly Erie International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Erie International Airport (ERI) to Asheville Regional Airport (AVL)plane plane ERI - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 54m
    $89–407

  3. Train, bus via Farragut

    1. Take the train from Erie Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited
    2. Take the bus from New York to Knoxvillebus bus Nyc
    24h 51m
    $471–695

  4. Drive  594.4 mi

    1. Drive from Erie to Knoxvillecar car 594.4 mi
    9h 59m
    $109–157

  5. Train to Cleveland-Hopkins International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Erie Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Mcghee Tyson Airport (TYS)plane plane CLE - TYS
    7h 27m
    $300–1,353

  6. Bus to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Erie to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    8h 12m
    $264–1,222

  7. Train, bus

    1. Take the train from Erie Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    24h 55m
    $426–605

  8. Bus

    1. Take the bus from Erie to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh Intermodal Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    31h
    $194–261

Erie International Airport (ERI) to Mcghee Tyson Airport (TYS) flights

Calendar10Weekly Planes
Duration5h 38mAverage Duration
Ticket$174Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Erie to Knoxville.ExpandLaunch map view
  • Distance: 506.8 mi
  • Duration: 6h 30m

What companies run services between Erie, PA, USA and Knoxville, TN, USA?

American Airlines flies from Erie International Airport (ERI) to Mcghee Tyson Airport (TYS) once daily. Alternatively, you can take a bus from Erie to Knoxville Station Hall of Fame via Pittsburgh Intermodal Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 31h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There