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How to get fromErie to Knoxvilleby plane, bus (Greyhound, Flixbus), car, train, or bus

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There are 9 ways to get from Erie to Knoxville by plane, bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Erie International Airport to Mcghee Tyson Airport

    best
    1. Fly from Erie International Airport (ERI) to Mcghee Tyson Airport (TYS)plane plane ERI - TYS
    6h 37m
    $187–772

  2. Fly Erie International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Erie International Airport (ERI) to Asheville Regional Airport (AVL)plane plane ERI - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    8h 53m
    $89–397

  3. Bus

    1. Take the bus from Erie, PA to Buffalo, NYbus bus
    2. Take the bus from Buffalo to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    24h 16m
    $262–416

  4. Drive 594.4 mi

    1. Drive from Erie to Knoxvillecar car 594.4 mi
    9h 59m
    $109–157

  5. Train to Cleveland-Hopkins International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Erie Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Mcghee Tyson Airport (TYS)plane plane CLE - TYS
    7h 24m
    $239–985

  6. Bus to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Erie, PA to Buffalo, NYbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    7h 42m
    $255–1,141

  7. Train, bus via Farragut

    1. Take the train from Erie Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited
    2. Take the bus from New York to Knoxvillebus bus Nyc
    24h 51m
    $354–595

  8. Train, bus

    1. Take the train from Erie Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    24h 55m
    $309–505

  9. Bus via Pittsburgh

    1. Take the bus from Erie to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh Intermodal Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    31h
    $210–291

Erie International Airport (ERI) to Mcghee Tyson Airport (TYS) flights

Calendar23Weekly Planes
Duration5h 28mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from Erie to Knoxville.ExpandLaunch map view
  • Distance: 506.8 mi
  • Duration: 6h 37m

What companies run services between Erie, PA, USA and Knoxville, TN, USA?

American Airlines and United Airlines fly from Erie International Airport (ERI) to Mcghee Tyson Airport (TYS) 3 times a day. Alternatively, you can take a bus from Erie, PA to Knoxville via Buffalo, NY, Buffalo, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 24h 16m.

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