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How to get fromErie to Louisvilleby train, bus, car, plane, or bus (Flixbus, Greyhound, Amtrak)

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There are 8 ways to get from Erie to Louisville by train, bus, car, plane, or bus (Flixbus, Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus via Toledo

    best
    1. Take the train from Erie Station to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    11h 57m
    $155–281

  2. Drive  442.5 mi

    cheapest
    1. Drive from Erie to Louisvillecar car 442.5 mi
    7h 29m
    $81–117

  3. Train, bus (Amtrak)

    1. Take the train from Erie Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    17h 45m
    $362–584

  4. Fly from Erie International Airport

    1. Fly from Erie International Airport (ERI) to Louisville International Airport (SDF)plane plane ERI - SDF
    7h 59m
    $123–705

  5. Train, bus #2

    1. Take the train from Erie Station to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    12h 12m
    $169–276

  6. Bus

    1. Take the bus from Erie to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    12h 42m
    $92–154

  7. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Erie Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Louisville International Airport (SDF)plane plane CLE - SDF
    8h 12m
    $176–836

  8. Bus to Buffalo Niagara International Airport, fly

    1. Take the bus from Erie to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    8h 55m
    $140–755

Erie to Louisville by train and bus

Calendar7Weekly Services
Duration11h 57mAverage Duration
Ticket$155Cheapest Price
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Comparing Your Travel Options

Map of how to get from Erie to Louisville.ExpandLaunch map view
  • Distance: 536.9 mi
  • Duration: 11h 57m

What companies run services between Erie, PA, USA and Louisville, KY, USA?

American Airlines flies from Erie International Airport (ERI) to Louisville International Airport (SDF) 4 times a day. Alternatively, you can take a bus from Erie to Louisville, KY via Columbus, E Main St & S 5Th St, S Grant Ave & E Mound St, Columbus, and Indianapolis Union Station in around 12h 42m.

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