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How to get fromErie to Mayo Clinicby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 7 ways to get from Erie to Mayo Clinic by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Erie International Airport to Rochester

    best
    1. Fly from Erie International Airport (ERI) to Rochester (RST)plane plane ERI - RST
    8h 45m
    $86–403

  2. Train, bus via Madison

    1. Take the train from Erie Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    18h 40m
    $216–413

  3. Bus

    1. Take the bus from Erie to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    19h 40m
    $148–293

  4. Drive 788.9 mi

    1. Drive from Erie to Mayo Cliniccar car 788.9 mi
    13h 14m
    $144–208

  5. Train to Cleveland-Hopkins International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Erie Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 28m
    $636–1,117

  6. Bus to Buffalo Niagara International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Erie, PA to Buffalo, NYbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 39m
    $192–823

  7. Train, bus

    1. Take the train from Erie Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    20h 5m
    $299–593

Erie to Mayo Clinic by train, bus, and foot

Calendar14Weekly Services
Duration20h 5mAverage Duration
Ticket$299Cheapest Price
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Questions & Answers

Map of how to get from Erie to Mayo Clinic.ExpandLaunch map view
  • Distance: 658 mi
  • Duration: 8h 45m

What companies run services between Erie, PA, USA and Mayo Clinic, MN, USA?

American Airlines flies from Erie International Airport (ERI) to Rochester (RST) once daily. Alternatively, you can take a bus from Erie to Mayo Clinic via Cleveland Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 19h 40m.

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