There are 6 ways to get from Escanaba to Mayo Clinic by bus, car, plane, bus (Greyhound), or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Milwaukee
best- Take the bus from Escanaba to Milwaukeebus It 59
- Take the bus from Milwaukee to Rochesterbus Jefferson Lines 966
12h 9m$121–189Drive 363.5 mi
cheapest- Drive from Escanaba to Mayo Cliniccar 363.5 mi
7h 28m$67–96Fly to Rochester
- Fly from Delta County Airport (ESC) to Rochester (RST)plane ESC - RST
8h 15m$69–401Bus
- Take the bus from Escanaba to Green Baybus
- Take the bus from Green Bay Transit Center to Minneapolis Bus Stationbus
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
13h 52m$133–186Bus, train
- Take the bus from Escanaba to Milwaukeebus
- Take the train from Milwaukee to St. Paul-Minneapolistrain
- Take the bus from St. Paul to Rochesterbus
14h 46m$164–359Fly to Minneapolis–Saint Paul International Airport, bus
- Fly from Delta County Airport (ESC) to Minneapolis–Saint Paul International Airport (MSP)plane ESC - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
4h 40m$128–461
Delta County Airport (ESC) to Rochester (RST) flights
Comparing Your Travel Options
The cheapest way to get from Escanaba to Mayo Clinic is to drive which costs $65 - $100 and takes 7h 28m.
The fastest way to get from Escanaba to Mayo Clinic is to fly and bus which takes 4h 40m and costs $120 - $470.
No, there is no direct bus from Escanaba to Mayo Clinic. However, there are services departing from Escanaba and arriving at Rochester via Milwaukee. The journey, including transfers, takes approximately 12h 9m.
The distance between Escanaba and Mayo Clinic is 516 miles. The road distance is 365.6 miles.
The best way to get from Escanaba to Mayo Clinic without a car is to bus via Milwaukee which takes 12h 9m and costs $120 - $190.
It takes approximately 12h 9m to get from Escanaba to Mayo Clinic, including transfers.
Escanaba to Mayo Clinic bus services, operated by Indian Trails, depart from Escanaba station.
The best way to get from Escanaba to Mayo Clinic is to bus via Milwaukee which takes 12h 9m and costs $120 - $190. Alternatively, you can fly, which costs $65 - $410 and takes 8h 15m.
Escanaba to Mayo Clinic bus services, operated by Indian Trails, arrive at Milwaukee station.
Yes, the driving distance between Escanaba to Mayo Clinic is 366 miles. It takes approximately 7h 28m to drive from Escanaba to Mayo Clinic.
What companies run services between Escanaba, MI, USA and Mayo Clinic, MN, USA?
You can take a vehicle from Escanaba to Mayo Clinic via Escanaba, Milwaukee, and Rochester in around 12h 9m. Alternatively, Delta flies from Delta County Airport (ESC) to Rochester (RST) 3 times a day.
- Website
- delta.com
Flights from Delta County Airport to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 6h 45m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $50–340
Flights from Delta County Airport to Rochester via Detroit, Minneapolis–Saint Paul International Airport
- Ave. Duration
- 10h 29m
- When
- Every day
- Estimated price
- $85–440
Flights from Delta County Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 23m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $60–390
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to St. Paul-Minneapolis
- Ave. Duration
- 5h 52m
- Frequency
- 3 times a day
- Estimated price
- $85–230
- Website
- Amtrak
- Phone
- +1 989-725-5105
- Website
- Indian Trails
Bus from Escanaba to Milwaukee
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- Indian Trails
Bus from Escanaba to Green Bay
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $20–40
- Website
- Indian Trails
Bus from Escanaba to Milwaukee
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- Indian Trails
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Milwaukee to Rochester
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Green Bay Transit Center to Minneapolis Bus Station
- Ave. Duration
- 6h 30m
- Frequency
- Once daily
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
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Booking & Getting There
There are 77+ hotels available in Mayo Clinic.










