There are 7 ways to get from Florence to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
- Take the train from Roma Termini to Iserniatrain Re
4h 44m€51–116Bus via Rome
cheapest- Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus 510 / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 25m€25–65Drive 428.2 km
- Drive from Florence to Iserniacar 428.2 km
4h 6m€67–96Fly to Fiumicino International Airport, train
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane FLR - FCO
- Take the train from Roma Termini to Iserniatrain
5h 53m€89–239Train via Firenze Santa Maria Novella
- Take the train from Firenze Santa Maria Novella to Roma Terminitrain 8111 / ...
- Take the train from Roma Termini to Iserniatrain Re
5h 15m€57–105Bus
- Take the bus from Florence Villa Constanza Bus Station to Iserniabus 433
9h 54m€50–85Fly to Naples Airport, train
- Fly from Florence Peretola Airport (FLR) to Naples Airport (NAP)plane FLR - NAP
- Take the train from Caserta to Iserniatrain
7h 55m€95–255
Florence to Isernia by train (Trenitalia)
Questions & Answers
The cheapest way to get from Florence to Isernia is to bus via Rome which costs €25 - €65 and takes 6h 25m.
The fastest way to get from Florence to Isernia is to drive which takes 4h 6m and costs €65 - €100.
Yes, there is a direct bus departing from Florence Villa Constanza Bus Station station and arriving at Isernia. Services depart once daily, and operate every day. The journey takes approximately 9h 54m.
No, there is no direct train from Florence to Isernia. However, there are services departing from Firenze S.M.N. and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 4h 44m.
The distance between Florence and Isernia is 447 km. The road distance is 428.2 km.
The best way to get from Florence to Isernia without a car is to train which takes 4h 44m and costs €50 - €120.
It takes approximately 4h 44m to get from Florence to Isernia, including transfers.
Florence to Isernia bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Isernia train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
The best way to get from Florence to Isernia is to train which takes 4h 44m and costs €50 - €120. Alternatively, you can bus via Rome, which costs €25 - €65 and takes 6h 25m.
What companies run services between Florence, Italy and Isernia, Italy?
You can take a train from Firenze S.M.N. to Isernia via Roma Termini in around 4h 44m. Alternatively, you can take a bus from Florence Villa Constanza Bus Station to Isernia via Roma, Autostazione Tiburtina in around 6h 25m.
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 53 min
- When
- Every day
- Estimated price
- €60–180
Flights from Florence Peretola Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 31m
- When
- Every day
- Estimated price
- €130–200
- Website
- easyjet.com
Flights from Florence Peretola Airport to Naples Airport via Nice
- Ave. Duration
- 3h 45m
- When
- Monday and Wednesday
- Estimated price
- €85–250
Flights from Florence Peretola Airport to Naples Airport via Olbia
- Ave. Duration
- 3h 50m
- When
- Wednesday
- Estimated price
- €85–250
Flights from Florence Peretola Airport to Naples Airport via Palermo
- Ave. Duration
- 4h 40m
- When
- Monday, Wednesday, and Friday
- Estimated price
- €60–230
- Website
- ryanair.com
Flights from Florence Peretola Airport to Naples Airport via Catania
- Ave. Duration
- 4h
- When
- Monday, Friday, and Sunday
- Estimated price
- €90–220
- Phone
- +39 06 68475475
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 36m
- Frequency
- Every 15 minutes
- Estimated price
- €35–80
- Schedules at
- Trenitalia Frecce
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 3h 51m
- Frequency
- Every 4 hours
- Estimated price
- €30–55
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €11–19
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Estimated price
- €27–60
- Website
- Trenitalia Intercity
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze Santa Maria Novella to Roma Termini
- Ave. Duration
- 2h 7m
- Frequency
- Every 30 minutes
- Estimated price
- €30–65
- Website
- Italo Treno
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 15m
- Frequency
- Hourly
- Estimated price
- €21–35
- Website
- Flixbus
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- €13–22
- Website
- Flixbus
Bus from Florence Villa Constanza Bus Station to Isernia
- Ave. Duration
- 9h 54m
- Frequency
- Once daily
- Estimated price
- €50–85
- Website
- Flixbus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- €17–40
- Website
- Itabus S.p.A.
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 30m
- Frequency
- Once daily
- Estimated price
- €24–45
- Website
- BlaBlaCar Bus
- Phone
- +39 0972 24590
- [email protected]
- Website
- autolineemoretti.it
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 50m
- Frequency
- 3 times a week
- Estimated price
- €19–22
- Schedules at
- autolineemoretti.it
- Phone
- +39 0874 64744
- [email protected]
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Want to know more about travelling around Italy
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More Questions & Answers
Florence to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Florence to Isernia train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
Yes, the driving distance between Florence to Isernia is 428 km. It takes approximately 4h 6m to drive from Florence to Isernia.
Book your Florence to Isernia train tickets online with Omio.
Book your Florence to Isernia bus tickets online with Omio and FlixBus.
There are 482+ hotels available in Isernia.

































