There are 6 ways to get from Florence to Sepino by train, bus, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus
best- Take the train from Firenze S.M.N. to Napoli Afragolatrain Fr
- Take the bus from Maddaloni to Sepinobus 33-Ce / ...
5h 51m€62–121Bus via Rome
cheapest- Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus 510 / ...
- Take the bus from Roma, Autostazione Tiburtina to Boianobus Rome Tiburtina
8h 20m€25–54Drive 470.3 km
- Drive from Florence to Sepinocar 470.3 km
4h 41m€85–123Fly, train, bus
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane FLR - FCO
- Take the train from Roma Termini to Napoli Afragolatrain
- Take the bus from Maddaloni to Sepinobus
6h 57m€95–271Train
- Take the train from Firenze Santa Maria Novella to Roma Tiburtinatrain 8902 / ...
- Take the train from Roma Tiburtina to Boianotrain Re
6h 43m€56–85Bus
- Take the bus from Florence Villa Constanza Bus Station to Caserta Piazza Carlo Terzobus Lyon
- Take the bus from Maddaloni to Sepinobus 33-Ce / ...
8h 54m€30–52
Florence to Sepino by bus and foot
Comparing Your Travel Options
The cheapest way to get from Florence to Sepino is to bus which costs €30 - €55 and takes 8h 54m.
The fastest way to get from Florence to Sepino is to drive which takes 4h 41m and costs €85 - €130.
No, there is no direct bus from Florence station to Sepino. However, there are services departing from Florence Villa Constanza Bus Station and arriving at Sepino via Roma, Autostazione Tiburtina and Bojano. The journey, including transfers, takes approximately 8h 20m.
No, there is no direct train from Florence to Sepino. However, there are services departing from Firenze Santa Maria Novella and arriving at Boiano via Roma Tiburtina. The journey, including transfers, takes approximately 6h 43m.
The distance between Florence and Sepino is 569 km. The road distance is 470.3 km.
The best way to get from Florence to Sepino without a car is to train and bus which takes 5h 51m and costs €60 - €130.
It takes approximately 5h 51m to get from Florence to Sepino, including transfers.
Florence to Sepino bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Sepino train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
The best way to get from Florence to Sepino is to bus via Rome which takes 8h 20m and costs €25 - €55. Alternatively, you can train, which costs €55 - €90 and takes 6h 43m.
What companies run services between Florence, Italy and Sepino, Italy?
You can take a bus from Florence Villa Constanza Bus Station to Sepino via Roma, Autostazione Tiburtina, Boiano, and Bojano in around 8h 20m. Alternatively, you can take a train from Firenze Santa Maria Novella to Sepino via Roma Tiburtina, Boiano, and Bojano in around 6h 43m.
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €60–150
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Napoli Afragola
- Ave. Duration
- 2h 49m
- Frequency
- Hourly
- Estimated price
- €65–110
- Website
- Trenitalia Frecce
Train from Roma Termini to Napoli Afragola
- Ave. Duration
- 55 min
- Frequency
- Every 30 minutes
- Estimated price
- €29–50
- Website
- Trenitalia Frecce
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze S.M.N. to Napoli Afragola
- Ave. Duration
- 3h 14m
- Frequency
- Twice daily
- Estimated price
- €50–90
- Website
- Italo Treno
Train from Roma Termini to Napoli Afragola
- Ave. Duration
- 58 min
- Frequency
- Hourly
- Estimated price
- €24–40
- Website
- Italo Treno
Train from Firenze Santa Maria Novella to Roma Tiburtina
- Ave. Duration
- 1h 26m
- Frequency
- Every 30 minutes
- Estimated price
- €29–50
- Website
- Italo Treno
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Roma Termini to Napoli Afragola
- Ave. Duration
- 2h 53m
- Frequency
- Twice a week
- Estimated price
- €23–45
- Website
- Trenitalia Intercity
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Roma Tiburtina to Boiano
- Ave. Duration
- 2h 47m
- Frequency
- Twice daily
- Estimated price
- €25–35
- Website
- Trenitalia
- Phone
- 800 901 142
- [email protected]
- Website
- aircampania.it
Bus from Maddaloni to Sepino
- Ave. Duration
- 1h 34m
- Frequency
- 3 times a day
- Estimated price
- €5–8
- Schedules at
- aircampania.it
Bus from Maddaloni to Sepino
- Ave. Duration
- 1h 34m
- Frequency
- 3 times a day
- Estimated price
- €5–8
- Schedules at
- aircampania.it
Bus from Maddaloni to Sepino
- Ave. Duration
- 1h 34m
- Frequency
- 3 times a day
- Estimated price
- €5–8
- Schedules at
- aircampania.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 15m
- Frequency
- Hourly
- Estimated price
- €24–40
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- €22–40
- Website
- BlaBlaCar Bus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- €14–25
- Website
- Itabus S.p.A.
Bus from Florence Villa Constanza Bus Station to Caserta Piazza Carlo Terzo
- Ave. Duration
- 5h 55m
- Frequency
- Once daily
- Estimated price
- €24–45
- Website
- Itabus S.p.A.
- Phone
- +39 0972 24590
- [email protected]
- Website
- autolineemoretti.it
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 50m
- Frequency
- 3 times a week
- Estimated price
- €19–22
- Schedules at
- autolineemoretti.it
- Phone
- +39 0874 64744
- [email protected]
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Boiano
- Ave. Duration
- 2h 35m
- Frequency
- 3 times a day
- Estimated price
- €10–15
- Schedules at
- atm-molise.it
Want to know more about travelling around Italy
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Booking & Getting There
Florence to Sepino bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Florence to Sepino train services, operated by ItaloTreno, arrive at Roma Tiburtina station.
Yes, the driving distance between Florence to Sepino is 470 km. It takes approximately 4h 41m to drive from Florence to Sepino.
There are 406+ hotels available in Sepino.









































