There are 6 ways to get from Florence to Sepino by train, bus, car, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus
best- Take the train from Firenze Santa Maria Novella to Napoli Afragolatrain 8913 / ...
- Take the bus from Maddaloni to Sepinobus 33-Ce / ...
6h€63–102Bus via Rome
cheapest- Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus 510 / ...
- Take the bus from Roma, Autostazione Tiburtina to Boianobus Rome Tiburtina
8h 20m€25–53Drive 470.3 km
- Drive from Florence to Sepinocar 470.3 km
4h 41m€86–123Train
- Take the train from Firenze Santa Maria Novella to Roma Tiburtinatrain 8902 / ...
- Take the train from Roma Tiburtina to Boianotrain Re
6h 43m€56–86Train via Rome
- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
- Take the train from Roma Termini to Boianotrain Re
6h 47m€55–97Bus
- Take the bus from Firenze - Piazzale Montelungo to Napoli, Autostazione Metroparkbus
- Take the bus from Napoli, Autostazione Metropark to Sepinobus 33-Ce / ...
8h 35m€32–45
Florence to Sepino by bus and foot
Comparing Your Travel Options
The cheapest way to get from Florence to Sepino is to bus via Rome which costs €25 - €55 and takes 8h 20m.
The fastest way to get from Florence to Sepino is to drive which takes 4h 41m and costs €85 - €130.
No, there is no direct bus from Florence station to Sepino. However, there are services departing from Florence Villa Constanza Bus Station and arriving at Sepino via Roma, Autostazione Tiburtina and Bojano. The journey, including transfers, takes approximately 8h 20m.
No, there is no direct train from Florence to Sepino. However, there are services departing from Firenze Santa Maria Novella and arriving at Boiano via Roma Tiburtina. The journey, including transfers, takes approximately 6h 43m.
The distance between Florence and Sepino is 569 km. The road distance is 470.3 km.
The best way to get from Florence to Sepino without a car is to train and bus which takes 6h and costs €60 - €110.
It takes approximately 6h to get from Florence to Sepino, including transfers.
Florence to Sepino bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Sepino train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
The best way to get from Florence to Sepino is to bus via Rome which takes 8h 20m and costs €25 - €55. Alternatively, you can train, which costs €55 - €90 and takes 6h 43m.
What companies run services between Florence, Italy and Sepino, Italy?
You can take a bus from Florence Villa Constanza Bus Station to Sepino via Roma, Autostazione Tiburtina, Boiano, and Bojano in around 8h 20m. Alternatively, you can take a train from Firenze Santa Maria Novella to Sepino via Roma Tiburtina, Boiano, and Bojano in around 6h 43m.
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze Santa Maria Novella to Napoli Afragola
- Ave. Duration
- 2h 48m
- Frequency
- Hourly
- Estimated price
- €55–90
- Website
- Italo Treno
Train from Firenze Santa Maria Novella to Roma Tiburtina
- Ave. Duration
- 1h 26m
- Frequency
- Every 30 minutes
- Estimated price
- €30–50
- Website
- Italo Treno
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 47m
- Frequency
- 5 times a day
- Estimated price
- €30–50
- Website
- Italo Treno
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Roma Tiburtina to Boiano
- Ave. Duration
- 2h 47m
- Frequency
- 6 times a week
- Estimated price
- €25–35
- Website
- Trenitalia
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 3h 51m
- Frequency
- 4 times a day
- Estimated price
- €30–45
- Website
- Trenitalia
Train from Roma Termini to Boiano
- Ave. Duration
- 2h 41m
- Frequency
- 5 times a day
- Estimated price
- €25–35
- Website
- Trenitalia
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 36m
- Frequency
- Every 30 minutes
- Estimated price
- €35–60
- Website
- Trenitalia Frecce
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- 6 times a week
- Estimated price
- €28–55
- Website
- Trenitalia Intercity
- Phone
- 800 901 142
- [email protected]
- Website
- aircampania.it
Bus from Maddaloni to Sepino
- Ave. Duration
- 1h 34m
- Frequency
- 3 times a day
- Estimated price
- €5–8
- Schedules at
- aircampania.it
Bus from Napoli, Autostazione Metropark to Sepino
- Ave. Duration
- 2h 5m
- Frequency
- 3 times a day
- Estimated price
- €7–11
- Schedules at
- aircampania.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 15m
- Frequency
- Every 30 minutes
- Estimated price
- €24–40
- Website
- Flixbus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- €14–25
- Website
- Itabus S.p.A.
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 30m
- Frequency
- Once daily
- Estimated price
- €22–40
- Website
- BlaBlaCar Bus
- Phone
- +39 0972 24590
- [email protected]
- Website
- autolineemoretti.it
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 50m
- Frequency
- 3 times a week
- Estimated price
- €19–22
- Schedules at
- autolineemoretti.it
- Phone
- +39 0874 64744
- [email protected]
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Boiano
- Ave. Duration
- 2h 35m
- Frequency
- 3 times a day
- Estimated price
- €10–15
- Schedules at
- atm-molise.it
- Phone
- +39081/969167
- [email protected]
- Website
- TTI Leonettibus SRL
Bus from Firenze - Piazzale Montelungo to Napoli, Autostazione Metropark
- Ave. Duration
- 5h 30m
- Frequency
- Once a week
- Estimated price
- €25–35
- Website
- TTI Leonettibus SRL
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Booking & Getting There
Florence to Sepino bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Florence to Sepino train services, operated by ItaloTreno, arrive at Roma Tiburtina station.
Yes, the driving distance between Florence to Sepino is 470 km. It takes approximately 4h 41m to drive from Florence to Sepino.
There are 407+ hotels available in Sepino.







































