There are 6 ways to get from Florence to Sistine Chapel by train, bus, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, line 64 bus
best- Take the train from Firenze Santa Maria Novella to Roma Terminitrain 8111 / ...
- Take the bus from Termini to Cavalleggeri/S. Pietrobus 64 / ...
2h 17m€31–58Bus
cheapest- Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus 510 / ...
4h 24m€15–46Drive 275.9 km
- Drive from Florence to Sistine Chapelcar 275.9 km
2h 41m€50–72Fly from Florence Peretola Airport
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane FLR - FCO
3h 18m€65–207Train
- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
2h 19m€31–62Train to Bologna Guglielmo Marconi Airport, fly
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Fiumicino International Airport (FCO)plane BLQ - FCO
3h 56m€68–254
Florence to Sistine Chapel by bus and foot
Comparing Your Travel Options
The cheapest way to get from Florence to Sistine Chapel is to bus which costs €15 - €50 and takes 4h 24m.
The fastest way to get from Florence to Sistine Chapel is to train and line 64 bus which takes 2h 17m and costs €30 - €60.
No, there is no direct bus from Florence station to Sistine Chapel. However, there are services departing from Florence Villa Constanza Bus Station and arriving at Cavalleggeri/S. Pietro via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 24m.
No, there is no direct train from Florence to Sistine Chapel. However, there are services departing from Firenze S.M.N. and arriving at Cipro via Termini. The journey, including transfers, takes approximately 2h 19m.
The distance between Florence and Sistine Chapel is 266 km. The road distance is 275.9 km.
The best way to get from Florence to Sistine Chapel without a car is to train and line 64 bus which takes 2h 17m and costs €30 - €60.
It takes approximately 2h 17m to get from Florence to Sistine Chapel, including transfers.
Florence to Sistine Chapel bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Sistine Chapel train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
The best way to get from Florence to Sistine Chapel is to bus which takes 4h 24m and costs €15 - €50. Alternatively, you can fly, which costs €60 - €210 and takes 3h 18m, you could also train, which costs €30 - €65 and takes 2h 19m.
What companies run services between Florence, Italy and Sistine Chapel, Vatican City?
FlixBus operates a bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina hourly. Tickets cost €24–40 and the journey takes 3h 15m. Three other operators also service this route. Alternatively, ITA Airways flies from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO) 4 times a day.
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €60–150
Flights from Bologna Guglielmo Marconi Airport to Fiumicino International Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €55–140
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze Santa Maria Novella to Roma Termini
- Ave. Duration
- 1h 36m
- Frequency
- Every 30 minutes
- Estimated price
- €30–50
- Website
- Italo Treno
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 47m
- Frequency
- Twice daily
- Estimated price
- €30–50
- Website
- Italo Treno
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 38 min
- Frequency
- Once daily
- Estimated price
- €10–18
- Website
- Italo Treno
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 43m
- Frequency
- Every 20 minutes
- Estimated price
- €35–60
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 38 min
- Frequency
- Every 20 minutes
- Estimated price
- €12–21
- Website
- Trenitalia Frecce
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 4h 6m
- Frequency
- 3 times a day
- Estimated price
- €30–45
- Website
- Trenitalia
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 44m
- Frequency
- 4 times a day
- Estimated price
- €10–15
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Estimated price
- €29–55
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Twice daily
- Estimated price
- €10–18
- Website
- Trenitalia Intercity
- Phone
- +39 06 68475475
- [email protected]
- Website
- Trenitalia Eurocity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Twice daily
- Estimated price
- €27–70
- Website
- Trenitalia Eurocity
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +39 06 46951
- Website
- Atac Roma
Bus from Termini to Cavalleggeri/S. Pietro
- Ave. Duration
- 28 min
- Frequency
- Every 10 minutes
- Estimated price
- €2–9
- Website
- Atac Roma
- 100-minute intergrated ticket
- €2
- 24-hour ticket
- €9
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 15m
- Frequency
- Hourly
- Estimated price
- €24–40
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- €22–40
- Website
- BlaBlaCar Bus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- €14–25
- Website
- Itabus S.p.A.
- Phone
- +39 0972 24590
- [email protected]
- Website
- autolineemoretti.it
Bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 50m
- Frequency
- 3 times a week
- Estimated price
- €19–22
- Schedules at
- autolineemoretti.it
Want to know more about travelling around Vatican City
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
How to get from Florence to Rome
Read the travel guide
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
Booking & Getting There
Florence to Sistine Chapel bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Florence to Sistine Chapel train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
Yes, the driving distance between Florence to Sistine Chapel is 276 km. It takes approximately 2h 41m to drive from Florence to Sistine Chapel.
Book your Florence to Sistine Chapel bus tickets online with 12go.asia.
There are 21218+ hotels available in Sistine Chapel.