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How to get fromFlorence to Buffaloby plane, bus (Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

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There are 6 ways to get from Florence to Buffalo by plane, bus (Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Buffalo Niagara International Airport (BUF)plane plane FLO - BUF
    6h 32m
    $131–691

  2. Bus

    1. Take the bus from Florence, SC to New York, NYbus bus Florence
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    21h 43m
    $162–254

  3. Train (Amtrak)

    1. Take the train from Florence Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    22h 4m
    $346–702

  4. Drive 724.2 mi

    1. Drive from Florence to Buffalocar car 724.2 mi
    14h 47m
    $133–191

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Florence to Myrtle Beachbus bus
    2. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    7h 21m

  6. Bus via Charleston

    1. Take the bus from Florence to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus
    3. Take the bus from Charleston to Akronbus bus
    4. Take the bus from Akron to Buffalobus bus
    22h 10m

Florence to Buffalo by train (Amtrak)

Calendar14Weekly Trains
Duration22h 4mAverage Duration
Ticket$346Cheapest Price
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Questions & Answers

Map of how to get from Florence to Buffalo.ExpandLaunch map view
  • Distance: 622.6 mi
  • Duration: 6h 32m

What companies run services between Florence, SC, USA and Buffalo, NY, USA?

American Airlines flies from Florence Regional Airport (FLO) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, you can take a bus from Florence, SC to Buffalo via New York, NY, Delancey St-Essex St, 23 St, and New York Midtown in around 21h 43m.

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