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How to get fromFlorence to Buffaloby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

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There are 6 ways to get from Florence to Buffalo by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Buffalo Niagara International Airport (BUF)plane plane FLO - BUF
    6h 32m
    $125–690

  2. Drive  723.4 mi

    cheapest
    1. Drive from Florence to Buffalocar car 723.4 mi
    14h 48m
    $124–179

  3. Bus via Fayetteville

    1. Take the bus from Florence Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    21h 28m
    $161–264

  4. Train (Amtrak)

    1. Take the train from Florence Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    22h 4m
    $590–916

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 43m
    $129–661

  6. Bus

    1. Take the bus from Florence, SC to New York, NYbus bus Florence
    2. Take the bus from Port Authority Bus Terminal to Buffalobus bus Greyhound US0215 / ...
    22h 15m
    $147–374

Florence to Buffalo by bus

Calendar8Weekly Buses
Duration21h 28mAverage Duration
Ticket$161Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Buffalo.ExpandLaunch map view
  • Distance: 618.2 mi
  • Duration: 6h 32m

What companies run services between Florence, SC, USA and Buffalo, NY, USA?

American Airlines flies from Florence Regional Airport (FLO) to Buffalo Niagara International Airport (BUF) twice daily. Alternatively, you can take a bus from Florence Bus Station to Buffalo via Fayetteville Bus Station and Newark Penn Station in around 21h 28m.

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Want to know more about travelling around United States

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