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How to get fromFlorence to Buffaloby plane, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

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There are 6 ways to get from Florence to Buffalo by plane, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Buffalo Niagara International Airport (BUF)plane plane FLO - BUF
    6h 58m
    $115–640

  2. Train (Amtrak)

    1. Take the train from Florence Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    22h 4m
    $590–917

  3. Bus

    1. Take the bus from Florence, SC to New York, NYbus bus Florence
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    22h 11m
    $162–234

  4. Drive  755.5 mi

    1. Drive from Florence to Buffalocar car 755.5 mi
    13h 31m
    $138–200

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    7h 26m
    $128–610

  6. Bus via Raleigh

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Buffalobus bus
    23h
    $182–460

Florence to Buffalo by train (Amtrak)

Calendar14Weekly Trains
Duration22h 4mAverage Duration
Ticket$590Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Buffalo.ExpandLaunch map view
  • Distance: 618.2 mi
  • Duration: 6h 58m

What companies run services between Florence, SC, USA and Buffalo, NY, USA?

American Airlines flies from Florence Regional Airport (FLO) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, you can take a train from Florence Station to Buffalo via Ny Moynihan Train Hall At Penn Station in around 22h 4m.

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