There are 8 ways to get from Florence to Cheyenne by plane, bus, bus (Greyhound, Flixbus), train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Florence Regional Airport to Denver, bus
best- Fly from Florence Regional Airport (FLO) to Denver (DEN)plane FLO - DEN
- Take the bus from Denver International Airport Pickups to Warren AFBbus
9h 36m$190–702Bus to Myrtle Beach, fly to Cheyenne Airport
cheapest- Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus
- Fly from Myrtle Beach (MYR) to Cheyenne Airport (CYS)plane MYR - CYS
10h 49m$134–522Bus
- Take the bus from Florence Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Denver Union Stationbus
- Take the bus from Denver Union Station to Cheyennebus
40h 16m$317–498Train, bus
- Take the train from Florence Station to Selma Stationtrain
- Take the train from Selma Station to Raleigh Union Stationtrain
- Take the train from Raleigh Union Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Denvertrain
- Take the bus from Denver International Airport Pickups to Warren AFBbus
2d 5h$1,237–2,076Drive 1,699.9 mi
- Drive from Florence to Cheyennecar 1,699.9 mi
27h 52m$301–434Bus to Myrtle Beach, fly to Denver, bus
- Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus
- Fly from Myrtle Beach (MYR) to Denver (DEN)plane MYR - DEN
- Take the bus from Denver International Airport Pickups to Warren AFBbus
9h 46m$194–672Bus, bus to Charlotte Douglas International Airport, fly to Cheyenne Airport
- Take the bus from Florence Bus Station to Camdenbus
- Take the bus from Camden to Charlotte Bus Stationbus
- Fly from Charlotte Douglas International Airport (CLT) to Cheyenne Airport (CYS)plane CLT - CYS
12h 12m$157–461Train to Charleston International Airport, fly to Denver, bus
- Take the train from Florence Station to Charleston Amtrak Stationtrain
- Fly from Charleston International Airport (CHS) to Denver (DEN)plane CHS - DEN
- Take the bus from Denver International Airport Pickups to Warren AFBbus
11h 39m$396–924
Florence to Cheyenne by bus
Comparing Your Travel Options
The cheapest way to get from Florence to Cheyenne is to bus and fly which costs $150 - $470 and takes 12h 12m.
The fastest way to get from Florence to Cheyenne is to fly and bus which takes 9h 36m and costs $190 - $700.
No, there is no direct bus from Florence station to Cheyenne. However, there are services departing from Florence Bus Station and arriving at Cheyenne Regional Medical Center via Atlanta Bus Station, St Louis Bus Station, Denver Union Station and Greyhound. The journey, including transfers, takes approximately 40h 16m.
The distance between Florence and Cheyenne is 1541 miles. The road distance is 1709.8 miles.
The best way to get from Florence to Cheyenne without a car is to bus which takes 40h 16m and costs $310 - $500.
It takes approximately 9h 36m to get from Florence to Cheyenne, including transfers.
Florence to Cheyenne bus services, operated by Greyhound USA, depart from Florence Bus Station.
Florence to Cheyenne bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Cheyenne is 2h behind Florence. It is currently 2:52 AM in Florence and 12:52 AM in Cheyenne.
Yes, the driving distance between Florence to Cheyenne is 1710 miles. It takes approximately 27h 52m to drive from Florence to Cheyenne.
What companies run services between Florence, SC, USA and Cheyenne, WY, USA?
You can take a bus from Florence Bus Station to Cheyenne Regional Medical Center via Atlanta Bus Station, St Louis Bus Station, Denver Union Station, and Greyhound in around 40h 16m.
- Website
- delta.com
Flights from Myrtle Beach to Denver via Atlanta
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $120–550
Flights from Charleston International Airport to Denver via Atlanta
- Ave. Duration
- 6h 6m
- When
- Every day
- Estimated price
- $150–700
- Website
- united.com
Flights from Charlotte Douglas International Airport to Cheyenne Airport via Denver
- Ave. Duration
- 7h 14m
- When
- Every day
- Estimated price
- $120–550
Flights from Myrtle Beach to Cheyenne Airport via Denver
- Ave. Duration
- 11h 38m
- When
- Monday, Thursday, and Friday
- Estimated price
- $110–490
Flights from Myrtle Beach to Cheyenne Airport via Nashville, Denver
- Ave. Duration
- 11h 36m
- When
- Every day
- Estimated price
- $110–490
Flights from Myrtle Beach to Cheyenne Airport via Kansas City, Denver
- Ave. Duration
- 9h 58m
- When
- Saturday
- Estimated price
- $110–490
Flights from Myrtle Beach to Cheyenne Airport via Columbus, Denver
- Ave. Duration
- 12h 3m
- When
- Saturday
- Estimated price
- $120–550
Flights from Charleston International Airport to Denver
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $140–700
- Website
- southwest.com
Flights from Myrtle Beach to Denver
- Ave. Duration
- 3h 40m
- When
- Monday, Thursday, and Friday
- Estimated price
- $120–550
Flights from Myrtle Beach to Denver via Nashville
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $120–550
Flights from Myrtle Beach to Denver via Kansas City
- Ave. Duration
- 5h 40m
- When
- Saturday
- Estimated price
- $120–550
Flights from Charleston International Airport to Denver
- Ave. Duration
- 3h 55m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $140–700
Flights from Charleston International Airport to Denver via Nashville
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $140–700
Flights from Charleston International Airport to Denver via Dallas
- Ave. Duration
- 5h 45m
- When
- Saturday
- Estimated price
- $160–750
Flights from Charleston International Airport to Denver via St. Louis
- Ave. Duration
- 7h 15m
- When
- Tuesday and Wednesday
- Estimated price
- $150–700
- Website
- aa.com
Flights from Florence Regional Airport to Denver via Charlotte Douglas International Airport
- Ave. Duration
- 9h 23m
- When
- Every day
- Estimated price
- $130–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Florence Station to Selma Station
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $70–120
- Website
- Amtrak
Train from Selma Station to Raleigh Union Station
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $15–25
- Website
- Amtrak
Train from Raleigh Union Station to Chicago Union Station
- Ave. Duration
- 24h 28m
- Frequency
- Once daily
- Estimated price
- $550–950
- Website
- Amtrak
Train from Chicago Union Station to Denver
- Ave. Duration
- 18h 56m
- Frequency
- Once daily
- Estimated price
- $550–900
- Website
- Amtrak
Train from Florence Station to Charleston Amtrak Station
- Ave. Duration
- 1h 33m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Website
- Amtrak
Bus from Denver International Airport Pickups to Warren AFB
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $50–90
- Website
- Groome Transportation - Denvier, CO
- Schedules at
- Groome Transportation - Wyoming - DIA
Bus from Denver International Airport Pickups to Warren AFB
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $50–90
- Website
- Groome Transportation - Denvier, CO
- Schedules at
- Groome Transportation - Wyoming - DIA
Bus from Denver International Airport Pickups to Warren AFB
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $50–90
- Website
- Groome Transportation - Denvier, CO
- Schedules at
- Groome Transportation - Wyoming - DIA
Bus from Denver International Airport Pickups to Warren AFB
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $50–90
- Website
- Groome Transportation - Denvier, CO
- Schedules at
- Groome Transportation - Wyoming - DIA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Florence Bus Station to Atlanta Bus Station
- Ave. Duration
- 6h 40m
- Frequency
- Twice daily
- Estimated price
- $55–85
- Website
- Greyhound
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $100–150
- Website
- Greyhound
Bus from St Louis Bus Station to Denver Union Station
- Ave. Duration
- 17h 15m
- Frequency
- Twice daily
- Estimated price
- $160–240
- Website
- Greyhound
Bus from Denver Union Station to Cheyenne
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $17–27
- Website
- Greyhound
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $12–19
- Website
- Greyhound
Bus from Florence Bus Station to Camden
- Ave. Duration
- 1h
- Frequency
- Twice daily
- Estimated price
- $9–14
- Website
- Greyhound
Bus from Camden to Charlotte Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $14–22
- Website
- Greyhound
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $12–19
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 21m
- Frequency
- 5 times a week
- Estimated price
- $85–130
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
There are 57+ hotels available in Cheyenne.






