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How to get fromFlorence to Chicagoby bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 9 ways to get from Florence to Chicago by bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Myrtle Beach, fly to Chicago Midway International Airport

    best
    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    5h 38m
    $95–417

  2. Bus to Myrtle Beach, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    6h 12m
    $75–327

  3. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    23h 40m
    $164–279

  4. Train (Amtrak)

    1. Take the train from Florence Station to Selma Stationtrain train
    2. Take the train from Selma Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    29h 23m
    $637–1,086

  5. Drive  843.4 mi

    1. Drive from Florence to Chicagocar car 843.4 mi
    15h 14m
    $154–223

  6. Train to Charleston International Airport, fly to Chicago Midway International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    7h 16m
    $143–549

  7. Bus, bus to Charlotte Douglas International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Chicago Midway International Airport (MDW)plane plane CLT - MDW
    8h
    $99–465

  8. Bus, bus to Charlotte Douglas International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Chicago O'Hare International Airport (ORD)plane plane CLT - ORD
    8h 23m
    $84–365

  9. Train, bus

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to Chicagobus bus
    24h 46m
    $140–275

Florence to Chicago by bus

Calendar14Weekly Buses
Duration23h 40mAverage Duration
Ticket$164Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Chicago.ExpandLaunch map view
  • Distance: 819.4 mi
  • Duration: 5h 38m

What companies run services between Florence, SC, USA and Chicago, IL, USA?

You can take a bus from Florence Bus Station to Chicago Bus Station via Atlanta Bus Station in around 23h 40m. Alternatively, you can take a train from Florence Station to Chicago Union Station via Selma Station and Raleigh Union Station in around 29h 23m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

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Need to know: Greyhound

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