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How to get fromFlorence to Clevelandby plane, bus (Greyhound), train (Amtrak), car, or bus

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There are 6 ways to get from Florence to Cleveland by plane, bus (Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Cleveland-Hopkins International Airport (CLE)plane plane FLO - CLE
    7h 5m
    $103–505

  2. Bus via Charleston

    1. Take the bus from Florence to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus
    3. Take the bus from Charleston, WV to Cleveland, OHbus bus
    17h 50m
    $120–252

  3. Train (Amtrak)

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train Palmetto / ...
    2. Take the train from Petersburg Amtrak Station to Cleveland Amtraktrain train Floridian
    20h 36m
    $268–546

  4. Drive 608.9 mi

    1. Drive from Florence to Clevelandcar car 608.9 mi
    11h 2m
    $112–161

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Florence to Myrtle Beachbus bus
    2. Fly from Myrtle Beach (MYR) to Cleveland-Hopkins International Airport (CLE)plane plane MYR - CLE
    5h 23m
    $139–530

  6. Bus

    1. Take the bus from Florence to Charlottebus bus
    2. Take the bus from Charlotte to Columbusbus bus
    3. Take the bus from Columbus, Ohio Greyhound Station to Cleveland Ohio Greyhound Stationbus bus
    24h 7m
    $216–305

Florence to Cleveland by bus

Calendar7Weekly Buses
Duration17h 50mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Florence to Cleveland.ExpandLaunch map view
  • Distance: 525.4 mi
  • Duration: 7h 5m

What companies run services between Florence, SC, USA and Cleveland, OH, USA?

American Airlines flies from Florence Regional Airport (FLO) to Cleveland-Hopkins International Airport (CLE) twice daily. Alternatively, you can take a bus from Florence to Cleveland, OH via Charlotte Bus Station and Charleston, WV in around 17h 50m.

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