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How to get fromFlorence to Des Moinesby plane, bus (Greyhound, Flixbus, Amtrak), train, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Florence to Des Moines by plane, bus (Greyhound, Flixbus, Amtrak), train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Des Moines (DSM)plane plane FLO - DSM
    5h 20m
    $167–733

  2. Bus via Carbondale

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    4. Take the bus from St Louis Bus Station to Des Moinesbus bus
    28h 31m
    $196–396

  3. Train, bus via Galesburg

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    36h 59m
    $458–948

  4. Drive 1,131.8 mi

    1. Drive from Florence to Des Moinescar car 1,131.8 mi
    20h 1m
    $207–299

  5. Train to Fayetteville Municipal Airport, fly

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Fly from Fayetteville Municipal Airport (FAY) to Des Moines (DSM)plane plane FAY - DSM
    7h 13m
    $211–797

  6. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    28h 50m
    $191–386

  7. Train, bus

    1. Take the train from Florence Station to Selma Stationtrain train
    2. Take the train from Selma Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    37h 2m
    $452–956

Florence to Des Moines by bus

Calendar5Weekly Buses
Duration28h 31mAverage Duration
Ticket$196Cheapest Price
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Questions & Answers

Map of how to get from Florence to Des Moines.ExpandLaunch map view
  • Distance: 920 mi
  • Duration: 5h 20m

What companies run services between Florence, SC, USA and Des Moines, IA, USA?

American Airlines flies from Florence Regional Airport (FLO) to Des Moines (DSM) twice daily. Alternatively, you can take a bus from Florence Bus Station to Des Moines via Atlanta Bus Station, Carbondale, St. Louis, and St Louis Bus Station in around 28h 31m.

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