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How to get fromFlorence to Destinby plane, bus, taxi, or car

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There are 5 ways to get from Florence to Destin by plane, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Florence Regional Airport to Destin–Fort Walton Beach Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Destin–Fort Walton Beach Airport (VPS)plane plane FLO - VPS
    7h 32m
    $115–437

  2. Drive  542 mi

    cheapest
    1. Drive from Florence to Destincar car 542 mi
    10h 48m
    $90–130

  3. Bus, taxi

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to La Grange Bus Stationbus bus
    3. Take the bus from La Grange Bus Station to Mobilebus bus
    4. Take the bus from Loxley to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    16h 28m
    $255–341

  4. Fly Florence Regional Airport to Northwest Florida Beaches International Airport, taxi

    1. Fly from Florence Regional Airport (FLO) to Northwest Florida Beaches International Airport (ECP)plane plane FLO - ECP
    2. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    7h 36m
    $210–562

  5. Bus to Myrtle Beach, fly to Destin–Fort Walton Beach Airport

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Destin–Fort Walton Beach Airport (VPS)plane plane MYR - VPS
    6h 57m
    $123–437

Florence Regional Airport (FLO) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar15Weekly Planes
Duration7h 48mAverage Duration
Ticket$65Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Destin.ExpandLaunch map view
  • Distance: 491.3 mi
  • Duration: 7h 32m

What companies run services between Florence, SC, USA and Destin, FL, USA?

American Airlines, Delta, and Southwest Airlines fly from Florence Regional Airport (FLO) to Destin–Fort Walton Beach Airport (VPS) twice daily.

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