Rome2Rio

How to get fromFlorence to Floridaby bus (Flixbus), train (Amtrak), car, bus, plane, bus (Greyhound), or train

Find Transport to Florida

See all options

There are 10 ways to get from Florence to Florida by bus (Flixbus), train (Amtrak), car, bus, plane, bus (Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from Florence to Jacksonvillebus bus FlixBus N2472
    6h 11m
    $61–91

  2. Bus via Sumter (Greyhound)

    cheapest
    1. Take the bus from Florence Bus Station to Sumter Bus Stopbus bus Greyhound US0645S
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus Greyhound US0644S
    8h 40m
    $52–93

  3. Train (Amtrak)

    1. Take the train from Florence Station to Jacksonvilletrain train Silver Meteor
    6h 15m
    $98–217

  4. Drive  307.4 mi

    1. Drive from Florence to Jacksonvillecar car 307.4 mi
    5h 2m
    $57–81

  5. Bus to Myrtle Beach, fly to Tampa

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Tampa (TPA)plane plane MYR - TPA
    5h 34m
    $114–373

  6. Bus to Myrtle Beach, fly to Orlando

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    5h 52m
    $126–246

  7. Train to Charleston International Airport, fly to Fort Lauderdale–Hollywood International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CHS - FLL
    6h 41m
    $429–1,162

  8. Train to Charleston International Airport, fly to Tampa

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Tampa (TPA)plane plane CHS - TPA
    7h 3m
    $169–351

  9. Bus, bus to Charlotte Douglas International Airport, fly to Jacksonville

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Jacksonville (JAX)plane plane CLT - JAX
    8h 22m
    $85–441

  10. Bus, bus to Charlotte Douglas International Airport, fly to Tampa

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Tampa (TPA)plane plane CLT - TPA
    8h 12m
    $96–460

Florence to Florida by bus (Greyhound)

Calendar2Weekly Buses
Duration8h 40mAverage Duration
Ticket$52Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Florence to Florida.ExpandLaunch map view
  • Distance: 321.7 mi
  • Duration: 6h 11m

What companies run services between Florence, SC, USA and Florida, USA?

Flixbus USA operates a bus from Florence to Jacksonville 5 times a week. Tickets cost $45–70 and the journey takes 5h 45m. Alternatively, Amtrak operates a train from Florence Station to Jacksonville once daily. Tickets cost $80–200 and the journey takes 6h 6m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There