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How to get fromFlorence to Floridaby bus (Flixbus), train (Amtrak), car, bus, plane, bus (Greyhound), or train

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There are 10 ways to get from Florence to Florida by bus (Flixbus), train (Amtrak), car, bus, plane, bus (Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from Florence to Jacksonvillebus bus FlixBus N2472
    6h 11m
    $61–91

  2. Drive  307.4 mi

    cheapest
    1. Drive from Florence to Jacksonvillecar car 307.4 mi
    5h 2m
    $57–81

  3. Train (Amtrak)

    1. Take the train from Florence Station to Jacksonvilletrain train Silver Meteor
    6h 15m
    $202–307

  4. Bus to Myrtle Beach, fly to Fort Lauderdale–Hollywood International Airport

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    5h 23m
    $184–444

  5. Bus via Camden (Greyhound)

    1. Take the bus from Florence Bus Station to Camdenbus bus Greyhound US0641S / ...
    2. Take the bus from Camden to Jacksonvillebus bus Greyhound US0644S
    9h 50m
    $59–100

  6. Bus to Myrtle Beach, fly to Tampa

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Tampa (TPA)plane plane MYR - TPA
    5h 34m
    $114–373

  7. Bus to Myrtle Beach, fly to Orlando

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    5h 52m
    $126–246

  8. Train to Charleston International Airport, fly to Tampa

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Tampa (TPA)plane plane CHS - TPA
    7h 3m
    $148–636

  9. Bus, bus to Charlotte Douglas International Airport, fly to Jacksonville

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Jacksonville (JAX)plane plane CLT - JAX
    8h 26m
    $85–451

  10. Bus, bus to Charlotte Douglas International Airport, fly to Tampa

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Tampa (TPA)plane plane CLT - TPA
    8h 12m
    $96–470

Florence to Florida by bus (Greyhound)

Calendar7Weekly Buses
Duration9h 50mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Florida.ExpandLaunch map view
  • Distance: 321.7 mi
  • Duration: 6h 11m

What companies run services between Florence, SC, USA and Florida, USA?

Flixbus USA operates a bus from Florence to Jacksonville 5 times a week. Tickets cost $45–70 and the journey takes 5h 45m. Alternatively, Amtrak operates a train from Florence Station to Jacksonville once daily. Tickets cost $180–290 and the journey takes 6h 6m.

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Train operators
Bus operators

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Need to know: Greyhound

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