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How to get fromFlorence to Fort Myersby plane, bus (Flixbus), train, bus, car, or bus (Greyhound, Amtrak)

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There are 5 ways to get from Florence to Fort Myers by plane, bus (Flixbus), train, bus, car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Florence Regional Airport (FLO) to Ft. Myers (RSW)plane plane FLO - RSW
    7h 11m
    $93–437

  2. Bus (Flixbus)

    1. Take the bus from Florence to Orlando Bus Stationbus bus FlixBus N2472
    2. Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus bus FlixBus 2421
    14h 41m
    $120–208

  3. Train, bus

    1. Take the train from Florence Station to Kissimmee Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Orlando to Fort Myers Bus Stopbus bus FlixBus 2421
    18h
    $201–397

  4. Drive 598.7 mi

    1. Drive from Florence to Fort Myerscar car 598.7 mi
    10h 28m
    $110–158

  5. Bus via Jacksonville

    1. Take the bus from Florence Bus Station to Sumter Bus Stopbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Wildwood Amtrak Stationbus bus
    4. Take the bus from Wildwood to Fort Myersbus bus
    19h 35m
    $157–254

Florence to Fort Myers by train and bus

Calendar7Weekly Services
Duration18hAverage Duration
Ticket$201Cheapest Price
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Questions & Answers

Map of how to get from Florence to Fort Myers.ExpandLaunch map view
  • Distance: 560.1 mi
  • Duration: 7h 11m

What companies run services between Florence, SC, USA and Fort Myers, FL, USA?

American Airlines flies from Florence Regional Airport (FLO) to Ft. Myers (RSW) 3 times a day. Alternatively, you can take a vehicle from Florence to Fort Myers Bus Stop via Florence and Orlando Bus Station in around 14h 41m.

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