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How to get fromFlorence to Frederickby train (Amtrak), bus (Greyhound, Flixbus), car, train, plane, or bus

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There are 11 ways to get from Florence to Frederick by train (Amtrak), bus (Greyhound, Flixbus), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Florence Station to Washington Union Stationtrain train Palmetto / ...
    2. Take the train from Washington Union Station to FREDERICK MARC wbtrain train Marc
    10h 55m
    $108–245

  2. Bus

    cheapest
    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Frederick Bus Stationbus bus
    10h 55m
    $66–113

  3. Drive  437.3 mi

    1. Drive from Florence to Frederickcar car 437.3 mi
    7h 32m
    $80–116

  4. Train to Charleston International Airport, fly to Washington Dulles International Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Washington Dulles International Airport (IAD)plane plane CHS - IAD
    3. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    8h 59m
    $103–503

  5. Train, bus

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    3. Take the train from Washington Union Station to FREDERICK MARC wbtrain train
    11h 30m
    $69–134

  6. Train, bus to Myrtle Beach, fly to Baltimore-Washington International Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Baltimore-Washington International Airport (BWI)plane plane MYR - BWI
    4. Take the bus from Baltimore Airport to Frederick Bus Stationbus bus
    9h 29m
    $421–853

  7. Bus, bus to Charlotte Douglas International Airport, fly to Washington Dulles International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Washington Dulles International Airport (IAD)plane plane CLT - IAD
    4. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    10h 4m
    $127–360

  8. Train, bus to Myrtle Beach, fly to Ronald Reagan Washington National Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Ronald Reagan Washington National Airport (DCA)plane plane MYR - DCA
    4. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    10h 6m
    $127–562

  9. Bus, bus to Columbia, fly to Washington Dulles International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Columbia, SCbus bus
    3. Fly from Columbia (CAE) to Washington Dulles International Airport (IAD)plane plane CAE - IAD
    4. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    10h 33m
    $104–451

  10. Train, train to Raleigh-Durham International Airport, fly to Washington Dulles International Airport, bus

    1. Take the train from Florence Station to Selma Stationtrain train
    2. Take the train from Selma Station to Raleigh Union Stationtrain train
    3. Fly from Raleigh-Durham International Airport (RDU) to Washington Dulles International Airport (IAD)plane plane RDU - IAD
    4. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    10h 44m
    $98–480

  11. Train, bus to Myrtle Beach, fly to Washington Dulles International Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Washington Dulles International Airport (IAD)plane plane MYR - IAD
    4. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    12h 24m
    $115–468

Florence to Frederick by train

Calendar14Weekly Trains
Duration10h 55mAverage Duration
Ticket$108Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Frederick.ExpandLaunch map view
  • Distance: 463.1 mi
  • Duration: 10h 55m

What companies run services between Florence, SC, USA and Frederick, MD, USA?

You can take a train from Florence Station to FREDERICK MARC wb via Washington Union Station in around 10h 55m. Alternatively, you can take a bus from Florence Bus Station to Frederick Bus Station via Raleigh Bus Station and Washington Union Station in around 10h 55m.

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