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How to get fromFlorence to Frederickby bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, subway, or bus

Find Transport to Frederick

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There are 10 ways to get from Florence to Frederick by bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, subway, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Frederick Bus Stationbus bus
    10h 55m
    $66–113

  2. Train

    1. Take the train from Florence Station to Washington Union Stationtrain train Palmetto / ...
    2. Take the train from Washington Union Station to FREDERICK MARC wbtrain train Marc
    10h 57m
    $102–244

  3. Drive  437.3 mi

    1. Drive from Florence to Frederickcar car 437.3 mi
    7h 32m
    $80–116

  4. Train to Charleston International Airport, fly to Washington Dulles International Airport, subway, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Washington Dulles International Airport (IAD)plane plane CHS - IAD
    3. Take the subway from Washington Dulles International Airport, Silver Line Center Platform to Metro Center, Blue/Orange/Silver Line Center Platformsubway subway
    4. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    9h 17m
    $103–506

  5. Train, bus

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    3. Take the train from Washington Union Station to FREDERICK MARC wbtrain train
    11h 32m
    $67–134

  6. Bus, bus to Charlotte Douglas International Airport, fly to Washington Dulles International Airport, subway

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Washington Dulles International Airport (IAD)plane plane CLT - IAD
    4. Take the subway from Washington Dulles International Airport, Silver Line Center Platform to Metro Center, Blue/Orange/Silver Line Center Platformsubway subway
    5. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    10h 5m
    $130–346

  7. Train, bus to Myrtle Beach, fly to Baltimore-Washington International Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Baltimore-Washington International Airport (BWI)plane plane MYR - BWI
    4. Take the bus from Baltimore Airport to Frederick Bus Stationbus bus
    9h 29m
    $419–853

  8. Train, bus to Myrtle Beach, fly to Ronald Reagan Washington National Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Ronald Reagan Washington National Airport (DCA)plane plane MYR - DCA
    4. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    10h 6m
    $125–572

  9. Bus, bus to Columbia, fly to Washington Dulles International Airport, subway

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Columbia, SCbus bus
    3. Fly from Columbia (CAE) to Washington Dulles International Airport (IAD)plane plane CAE - IAD
    4. Take the subway from Washington Dulles International Airport, Silver Line Center Platform to Metro Center, Blue/Orange/Silver Line Center Platformsubway subway
    5. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    10h 49m
    $106–444

  10. Train, bus to Myrtle Beach, fly to Washington Dulles International Airport, subway, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Washington Dulles International Airport (IAD)plane plane MYR - IAD
    4. Take the subway from Washington Dulles International Airport, Silver Line Center Platform to Metro Center, Blue/Orange/Silver Line Center Platformsubway subway
    5. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    13h 19m
    $115–471

Florence to Frederick by bus

Calendar14Weekly Buses
Duration10h 55mAverage Duration
Ticket$66Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Frederick.ExpandLaunch map view
  • Distance: 456.3 mi
  • Duration: 10h 55m

What companies run services between Florence, SC, USA and Frederick, MD, USA?

You can take a bus from Florence Bus Station to Frederick Bus Station via Raleigh Bus Station and Washington Union Station in around 10h 55m. Alternatively, you can take a train from Florence Station to FREDERICK MARC wb via Washington Union Station in around 10h 57m.

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