There are 7 ways to get from Florence to Frederick by bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, subway, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, fly to Baltimore-Washington International Airport
best- Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus
- Fly from Myrtle Beach (MYR) to Baltimore-Washington International Airport (BWI)plane MYR - BWI
- Take the bus from Baltimore to Frederickbus
6h 21m$383–792Bus
cheapest- Take the bus from Florence Bus Station to Raleigh Bus Stationbus
- Take the bus from Raleigh Bus Station to Washington Union Stationbus
- Take the bus from Washington Union Station to Frederick Bus Stationbus
10h 55m$75–122Train
- Take the train from Florence Station to Washington Union Stationtrain Palmetto / ...
- Take the train from Washington Union Station to FREDERICK MARC wbtrain Marc
10h 57m$228–358Drive 437.3 mi
- Drive from Florence to Frederickcar 437.3 mi
7h 32m$80–116Bus, fly to Ronald Reagan Washington National Airport
- Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus
- Fly from Myrtle Beach (MYR) to Ronald Reagan Washington National Airport (DCA)plane MYR - DCA
- Take the bus from SHADY GROVE & station to Frederick Marc Stationbus
6h 59m$104–521Bus, fly to Washington Dulles International Airport, subway
- Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus
- Fly from Myrtle Beach (MYR) to Washington Dulles International Airport (IAD)plane MYR - IAD
- Take the subway from Washington Dulles International Airport, Silver Line Center Platform to Metro Center, Blue/Orange/Silver Line Center Platformsubway
- Take the bus from SHADY GROVE & station to Frederick Marc Stationbus
7h 41m$84–400Train, bus
- Take the train from Florence Station to Fayetteville Amtrak Stationtrain
- Take the bus from Fayetteville Bus Station to Washington Union Stationbus
- Take the train from Washington Union Station to FREDERICK MARC wbtrain
11h 32m$98–162
Florence to Frederick by bus
Comparing Your Travel Options
The cheapest way to get from Florence to Frederick is to bus which costs $75 - $130 and takes 10h 55m.
The fastest way to get from Florence to Frederick is to bus and fly which takes 6h 21m and costs $380 - $800.
No, there is no direct bus from Florence station to Frederick station. However, there are services departing from Florence Bus Station and arriving at Frederick Bus Station via Raleigh Bus Station and Washington Union Station. The journey, including transfers, takes approximately 10h 55m.
No, there is no direct train from Florence station to Frederick. However, there are services departing from Florence Station and arriving at FREDERICK MARC wb via Washington Union Station. The journey, including transfers, takes approximately 10h 57m.
The distance between Florence and Frederick is 524 miles. The road distance is 439.8 miles.
The best way to get from Florence to Frederick without a car is to bus which takes 10h 55m and costs $75 - $130.
It takes approximately 6h 21m to get from Florence to Frederick, including transfers.
Florence to Frederick bus services, operated by Greyhound USA, depart from Florence Bus Station.
Florence to Frederick train services, operated by Amtrak, depart from Florence Station.
The best way to get from Florence to Frederick is to bus which takes 10h 55m and costs $75 - $130. Alternatively, you can train, which costs $220 - $360 and takes 10h 57m.
What companies run services between Florence, SC, USA and Frederick, MD, USA?
You can take a bus from Florence Bus Station to Frederick Bus Station via Raleigh Bus Station and Washington Union Station in around 10h 55m. Alternatively, you can take a train from Florence Station to FREDERICK MARC wb via Washington Union Station in around 10h 57m.
- Website
- aa.com
Flights from Myrtle Beach to Baltimore-Washington International Airport via Charlotte
- Ave. Duration
- 3h 36m
- When
- Thursday, Friday, Sunday, and Tuesday
- Estimated price
- $65–380
Flights from Myrtle Beach to Ronald Reagan Washington National Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $75–480
Flights from Myrtle Beach to Ronald Reagan Washington National Airport via Charlotte
- Ave. Duration
- 3h 41m
- When
- Thursday, Friday, and Sunday
- Estimated price
- $85–550
Flights from Myrtle Beach to Washington Dulles International Airport via Charlotte
- Ave. Duration
- 3h 45m
- When
- Every day
- Estimated price
- $60–380
- Website
- southwest.com
Flights from Myrtle Beach to Baltimore-Washington International Airport
- Ave. Duration
- 1h 22m
- When
- Every day
- Estimated price
- $55–360
- Website
- united.com
Flights from Myrtle Beach to Washington Dulles International Airport
- Ave. Duration
- 1h 32m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $55–360
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Florence Station to Washington Union Station
- Ave. Duration
- 8h 16m
- Frequency
- Twice daily
- Estimated price
- $220–350
- Website
- Amtrak
Train from Florence Station to Fayetteville Amtrak Station
- Ave. Duration
- 1h 21m
- Frequency
- Twice daily
- Estimated price
- $45–70
- Website
- Amtrak
- Phone
- 1-866-743-3682
- Website
- Maryland Transit
Train from Washington Union Station to FREDERICK MARC wb
- Ave. Duration
- 1h 41m
- Frequency
- Twice daily
- Estimated price
- $2–12
- Website
- Maryland Transit
- Standard Fare
- $2–12
Train from Washington Union Station to FREDERICK MARC wb
- Ave. Duration
- 1h 41m
- Frequency
- Twice daily
- Estimated price
- $2–12
- Website
- Maryland Transit
- Standard Fare
- $2–12
Subway from Washington Dulles International Airport, Silver Line Center Platform to Metro Center, Blue/Orange/Silver Line Center Platform
- Ave. Duration
- 50 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–3
- Website
- Washington Metropolitan Area Transit Authority
- standard fare after 9:30 p.m
- $2–3
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $12–18
- Website
- Greyhound
Bus from Florence Bus Station to Raleigh Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $27–40
- Website
- Greyhound
Bus from Raleigh Bus Station to Washington Union Station
- Ave. Duration
- 4h 35m
- Frequency
- Every 4 hours
- Estimated price
- $45–70
- Website
- Greyhound
Bus from Washington Union Station to Frederick Bus Station
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $8–12
- Website
- Greyhound
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $12–18
- Website
- Greyhound
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $12–18
- Website
- Greyhound
- Phone
- +1 410-912-6000
- [email protected]
- Website
- BayRunner Shuttle
Bus from Baltimore to Frederick
- Ave. Duration
- 1h 15m
- Frequency
- 4 times a day
- Estimated price
- $70–110
- Schedules at
- BayRunner Shuttle
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Raleigh Bus Station to Washington Union Station
- Ave. Duration
- 5h 15m
- Frequency
- Twice daily
- Estimated price
- $40–65
- Schedules at
- Flixbus USA
Bus from Fayetteville Bus Station to Washington Union Station
- Ave. Duration
- 6h 30m
- Frequency
- Twice daily
- Estimated price
- $50–80
- Schedules at
- Flixbus USA
- Phone
- 1-866-743-3682
- Website
- Maryland Transit
Bus from SHADY GROVE & station to Frederick Marc Station
- Ave. Duration
- 47 min
- Frequency
- Once daily
- Estimated price
- $2
- Website
- Maryland Transit
Bus from SHADY GROVE & station to Frederick Marc Station
- Ave. Duration
- 47 min
- Frequency
- Once daily
- Estimated price
- $2
- Website
- Maryland Transit
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Florence to Frederick bus services, operated by Greyhound USA, arrive at Raleigh Bus Station.
Florence to Frederick train services, operated by Amtrak, arrive at Washington Union Station.
Yes, the driving distance between Florence to Frederick is 440 miles. It takes approximately 7h 32m to drive from Florence to Frederick.
Book your Florence to Frederick train tickets online with Omio.
Book your Florence to Frederick bus tickets online with Omio and FlixBus.
There are 57+ hotels available in Frederick.



















