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How to get fromFlorence to Frederickby bus (Greyhound, Flixbus), train (Amtrak), car, bus, plane, or train

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There are 8 ways to get from Florence to Frederick by bus (Greyhound, Flixbus), train (Amtrak), car, bus, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Frederick Bus Stationbus bus
    10h 14m
    $87–161

  2. Drive 437.6 mi

    cheapest
    1. Drive from Florence to Frederickcar car 437.6 mi
    7h 31m
    $80–116

  3. Train

    1. Take the train from Florence Station to Washington Union Stationtrain train Palmetto / ...
    2. Take the train from Washington Union Station to FREDERICK MARC wbtrain train Marc
    10h 55m
    $135–278

  4. Bus to Myrtle Beach, fly to Baltimore-Washington International Airport, bus

    1. Take the bus from Florence to Myrtle Beachbus bus
    2. Fly from Myrtle Beach (MYR) to Baltimore-Washington International Airport (BWI)plane plane MYR - BWI
    3. Take the bus from Baltimore Airport to Frederick Bus Stationbus bus
    6h 33m
    $361–807

  5. Train, bus

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    3. Take the train from Washington Union Station to FREDERICK MARC wbtrain train
    11h 30m
    $104–176

  6. Bus to Myrtle Beach, fly to Ronald Reagan Washington National Airport, bus

    1. Take the bus from Florence to Myrtle Beachbus bus
    2. Fly from Myrtle Beach (MYR) to Ronald Reagan Washington National Airport (DCA)plane plane MYR - DCA
    3. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    7h 11m
    $127–506

  7. Bus to Myrtle Beach, fly to Washington Dulles International Airport, bus

    1. Take the bus from Florence to Myrtle Beachbus bus
    2. Fly from Myrtle Beach (MYR) to Washington Dulles International Airport (IAD)plane plane MYR - IAD
    3. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    7h 29m
    $405–1,492

  8. Train to Charleston International Airport, fly to Washington Dulles International Airport, bus

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Washington Dulles International Airport (IAD)plane plane CHS - IAD
    3. Take the bus from Market St & Harrison St to Frederick Transit Stationbus bus
    8h 59m
    $589–1,191

Florence to Frederick by bus

Calendar22Weekly Buses
Duration10h 14mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Florence to Frederick.ExpandLaunch map view
  • Distance: 454.2 mi
  • Duration: 10h 14m

What companies run services between Florence, SC, USA and Frederick, MD, USA?

You can take a bus from Florence Bus Station to Frederick Bus Station via Raleigh Bus Station and Washington Union Station in around 10h 14m. Alternatively, you can take a train from Florence Station to FREDERICK MARC wb via Washington Union Station in around 10h 55m.

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