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How to get fromFlorence to Gainesvilleby bus (Flixbus), train, bus, car, plane, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Florence to Gainesville by bus (Flixbus), train, bus, car, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Florence Bus Station to Jacksonvillebus bus FlixBus 2433
    2. Take the bus from Jacksonville to Gainesvillebus bus FlixBus 2431
    7h 55m

  2. Bus via Sumter

    cheapest
    1. Take the bus from Florence to Sumterbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Gainesvillebus bus
    10h 55m
    $62–125

  3. Train, bus

    1. Take the train from Florence Station to Jacksonvilletrain train Silver Meteor
    2. Take the bus from Jacksonville to Gainesvillebus bus FlixBus 2431
    9h 30m
    $124–249

  4. Drive 371 mi

    1. Drive from Florence to Gainesvillecar car 371 mi
    6h 20m
    $68–98

  5. Fly from Florence Regional Airport

    1. Fly from Florence Regional Airport (FLO) to Gainesville Regional Airport (GNV)plane plane FLO - GNV
    5h 34m
    $72–354

  6. Bus to Myrtle Beach, fly

    1. Take the bus from Florence to Myrtle Beachbus bus
    2. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    7h 37m

Florence Regional Airport (FLO) to Gainesville Regional Airport (GNV) flights

Calendar28Weekly Planes
Duration7h 3mAverage Duration
Ticket$61Cheapest Price
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Questions & Answers

Map of how to get from Florence to Gainesville.ExpandLaunch map view
  • Distance: 383.1 mi
  • Duration: 7h 55m

What companies run services between Florence, SC, USA and Gainesville, FL, USA?

You can take a bus from Florence Bus Station to Gainesville via Jacksonville in around 7h 55m. Alternatively, American Airlines flies from Florence Regional Airport (FLO) to Gainesville Regional Airport (GNV) 4 times a day.

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