There are 5 ways to get from Florence to Indiana by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Florence Regional Airport (FLO) to Indianapolis (IND)plane FLO - IND
4h 49m$102–564Bus
cheapest- Take the bus from Florence Bus Station to Camdenbus
- Take the bus from Camden to Charlotte Bus Stationbus
- Take the bus from Charlotte to Columbusbus
- Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Richmond, INbus
- Take the bus from Richmond Bsb, IN to Indianapolis, INbus
20h 50m$81–217Bus via Atlanta
- Take the bus from Florence Bus Station to Atlanta Bus Stationbus Greyhound US0641S / ...
- Take the bus from Atlanta Bus Station to Indianapolisbus FlixBus 2512
19h 20m$127–203Train, bus (Amtrak)
- Take the train from Florence Station to Richmond Staples Mill Road Amtrak Stationtrain
- Take the bus from Richmond Staples Mill Road Station to Charlottesville Amtrak Stationbus
- Take the train from Charlottesville to Indianapolistrain
24h 30m$244–546Drive 660.9 mi
- Drive from Florence to Indianapoliscar 660.9 mi
12h 17m$121–175
Florence to Indiana by bus
Comparing Your Travel Options
The cheapest way to get from Florence to Indiana is to bus which costs $80 - $220 and takes 20h 50m.
The fastest way to get from Florence to Indiana is to fly which takes 4h 49m and costs $100 - $600.
No, there is no direct bus from Florence station to Indiana. However, there are services departing from Florence Bus Station and arriving at Indianapolis via Atlanta Bus Station. The journey, including transfers, takes approximately 19h 20m.
The distance between Florence and Indiana is 546 miles. The road distance is 664.7 miles.
The best way to get from Florence to Indiana without a car is to bus via Atlanta which takes 19h 20m and costs $120 - $210.
It takes approximately 4h 49m to get from Florence to Indiana, including transfers.
Florence to Indiana bus services, operated by Greyhound USA, depart from Florence Bus Station.
The best way to get from Florence to Indiana is to fly which takes 4h 49m and costs $100 - $600. Alternatively, you can bus via Atlanta, which costs $120 - $210 and takes 19h 20m.
Florence to Indiana bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Yes, the driving distance between Florence to Indiana is 665 miles. It takes approximately 12h 17m to drive from Florence to Indiana.
What companies run services between Florence, SC, USA and Indiana, USA?
American Airlines flies from Florence Regional Airport (FLO) to Indianapolis (IND) twice daily. Alternatively, you can take a bus from Florence Bus Station to Indianapolis via Atlanta Bus Station in around 19h 20m.
- Website
- aa.com
Flights from Florence Regional Airport to Indianapolis via Charlotte
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $90–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Florence Station to Richmond Staples Mill Road Amtrak Station
- Ave. Duration
- 5h 37m
- Frequency
- Twice daily
- Estimated price
- $75–180
- Website
- Amtrak
Train from Charlottesville to Indianapolis
- Ave. Duration
- 15h 23m
- Frequency
- 3 times a week
- Estimated price
- $150–350
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Florence Bus Station to Atlanta Bus Station
- Ave. Duration
- 6h 40m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Florence Bus Station to Camden
- Ave. Duration
- 1h
- Frequency
- Twice daily
- Estimated price
- $7–12
- Website
- Greyhound
Bus from Camden to Charlotte Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $12–20
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Book your Florence to Indiana bus tickets online with Omio and FlixBus.
There are 874+ hotels available in Indiana.





