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How to get fromFlorence to Indianapolisby plane, bus (Greyhound), train, bus, or car

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There are 6 ways to get from Florence to Indianapolis by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Florence Regional Airport (FLO) to Indianapolis (IND)plane plane FLO - IND
    5h 11m
    $102–504

  2. Bus via Atlanta

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S / ...
    2. Take the bus from Atlanta Bus Station to Indianapolisbus bus FlixBus 2512
    18h 20m

  3. Train, bus (Amtrak)

    1. Take the train from Florence Station to Richmond Staples Mill Road Amtrak Stationtrain train
    2. Take the bus from Richmond Staples Mill Road Station to Charlottesville Amtrak Stationbus bus
    3. Take the train from Charlottesville to Indianapolistrain train
    24h 30m
    $310–631

  4. Drive 660.9 mi

    1. Drive from Florence to Indianapoliscar car 660.9 mi
    12h 17m
    $121–175

  5. Bus, train

    1. Take the bus from Florence to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Ashlandbus bus
    3. Take the train from Ashland Amtrak Station to Indianapolistrain train
    21h 6m

  6. Bus

    1. Take the bus from Florence to Charlottebus bus
    2. Take the bus from Charlotte to Columbusbus bus
    3. Take the bus from Wilson & Ferrell Shell Station - Columbus to Indianapolis Union Stationbus bus
    21h 15m

Florence Regional Airport (FLO) to Indianapolis (IND) flights

Calendar21Weekly Planes
Duration6h 37mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Florence to Indianapolis.ExpandLaunch map view
  • Distance: 543.1 mi
  • Duration: 5h 11m

What companies run services between Florence, SC, USA and Indianapolis, IN, USA?

American Airlines flies from Florence Regional Airport (FLO) to Indianapolis (IND) 3 times a day. Alternatively, you can take a bus from Florence Bus Station to Indianapolis via Atlanta Bus Station in around 18h 20m.

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