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How to get fromFlorence to Ithacaby plane, bus, train, car, or bus (Greyhound)

Find Transport to Ithaca

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There are 7 ways to get from Florence to Ithaca by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport, bus

    best
    1. Fly from Florence Regional Airport (FLO) to Syracuse Hancock International Airport (SYR)plane plane FLO - SYR
    2. Take the bus from Syracuse Bus Station to Ithacabus bus
    7h 42m
    $172–904

  2. Drive  694 mi

    cheapest
    1. Drive from Florence to Ithacacar car 694 mi
    13h 14m
    $127–183

  3. Train, bus

    1. Take the train from Florence Station to Newark Penn Stationtrain train Palmetto / ...
    2. Take the bus from Newark Penn Station to Ithacabus bus FlixBus 2683 / ...
    17h 14m
    $374–577

  4. Bus

    1. Take the bus from Florence, SC to New York, NYbus bus Florence
    2. Take the bus from New York to Ithacabus bus Adt N806-D / ...
    18h 33m
    $135–307

  5. Bus to Myrtle Beach, fly, bus

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Syracuse Hancock International Airport (SYR)plane plane MYR - SYR
    3. Take the bus from Syracuse Bus Station to Ithacabus bus
    7h 58m
    $175–874

  6. Bus via Raleigh

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Willow Ave At 15Th Stbus bus 126 / ...
    4. Take the bus from New York, NY to Ithaca, NYbus bus
    19h 32m
    $194–372

  7. Train, bus via Albany

    1. Take the train from Florence Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Albany-Rensselaer Amtrak Stationtrain train
    3. Take the train from Albany-Rensselaer Amtrak Station to Syracuse Regional Transportation Centertrain train
    4. Take the bus from Syracuse Bus Station to Ithacabus bus
    21h 50m
    $473–861

Florence to Ithaca by train and bus

Calendar5Weekly Services
Duration17h 14mAverage Duration
Ticket$374Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Ithaca.ExpandLaunch map view
  • Distance: 716.5 mi
  • Duration: 7h 42m

What companies run services between Florence, SC, USA and Ithaca, NY, USA?

You can take a bus from Florence, SC to Ithaca via New York, NY, Centre St/Broome St, Madison Av/E 35 St, E 34 St/5 Av, and New York in around 18h 33m.

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